Cunha Filipe M, Saavedra Ana, Barbosa José, Freitas Paula, Carvalho Davide, Varela Ana
Serviço de Endocrinologia, Diabetes e Metabolismo, Centro Hospitalar de São João, Porto, Portugal; Faculdade de Medicina da Universidade do Porto, Porto, Portugal.
Serviço de Endocrinologia, Diabetes e Metabolismo, Centro Hospitalar de São João, Porto, Portugal; Faculdade de Medicina da Universidade do Porto, Porto, Portugal.
Surg Obes Relat Dis. 2016 Aug;12(7):1418-1423. doi: 10.1016/j.soard.2016.02.002. Epub 2016 Feb 3.
Obesity is associated with higher leukocyte counts, whereas weight loss decreases these counts. It is unknown if different bariatric surgery (BS) types have different effects on leukocytes.
The aim of the study was to determine predictors of leukocyte and their subset count variation in patients submitted to BS.
Tertiary care university hospital, Porto, Portugal.
This was a retrospective analysis of patients submitted to Roux-en-Y gastric bypass (RYGB), laparoscopic adjustable gastric banding (LAGB), or sleeve gastrectomy (SG). Leukocyte and subset counts were compared between baseline and 1-year postsurgery and between BS types. A multivariate linear regression model was built to study determinants of leukocyte and subset variation.
We analyzed 764 patients: 238 submitted to LAGB; 452 to RYGB, and 74 to SG. Mean age was 42 years and 86.6% were women. All BS types were associated with a decrease in leukocyte and neutrophil counts but the variation in body mass index and homeostatic model assessment (HOMA-IR) were the only variables independently associated with a decrease 1-year postsurgery. Monocytes increased in patients submitted to LAGB and decreased in those who underwent RYGB and SG. The BS type was independently associated with monocyte variation. Patients who underwent RYGB and SG had a decrease in monocyte counts of 77/µL and 62/µL, respectively, compared with LAGB.
Weight and insulin resistance are the main predictors of leukocyte and neutrophil variation after BS. The specific type of BS is a determinant of monocyte count variation independent of the amount of weight loss or the degree of insulin resistance improvement.
肥胖与白细胞计数升高相关，而体重减轻会降低这些计数。不同类型的减肥手术（BS）对白细胞是否有不同影响尚不清楚。
本研究的目的是确定接受减肥手术患者白细胞及其亚群计数变化的预测因素。
葡萄牙波尔图的三级护理大学医院。
这是一项对接受 Roux-en-Y 胃旁路术（RYGB）、腹腔镜可调节胃束带术（LAGB）或袖状胃切除术（SG）患者的回顾性分析。比较了基线和术后 1 年之间以及不同减肥手术类型之间的白细胞和亚群计数。建立了多元线性回归模型来研究白细胞和亚群变化的决定因素。
我们分析了 764 名患者：238 名接受 LAGB；452 名接受 RYGB，74 名接受 SG。平均年龄为 42 岁，86.6%为女性。所有减肥手术类型均与白细胞和中性粒细胞计数降低相关，但体重指数和稳态模型评估（HOMA-IR）的变化是术后 1 年与降低独立相关的唯一变量。接受 LAGB 的患者单核细胞增加，而接受 RYGB 和 SG 的患者单核细胞减少。减肥手术类型与单核细胞变化独立相关。与 LAGB 相比，接受 RYGB 和 SG 的患者单核细胞计数分别降低了 77/µL 和 62/µL。
体重和胰岛素抵抗是减肥手术后白细胞和中性粒细胞变化的主要预测因素。减肥手术的具体类型是单核细胞计数变化的决定因素，独立于体重减轻量或胰岛素抵抗改善程度。
