Lylloff Louise, Bathum Lise, Madsbad Sten, Grundtvig Josefine Liv Gilling, Nordgaard-Lassen Inge, Fenger Mogens
Obes Facts. 2017;10(4):386-395. doi: 10.1159/000478097. Epub 2017 Aug 23.
In obesity, which is a major contributor to insulin resistance and diabetes, the circulating level of S100A8/A9 (calprotectin) is elevated and declines after Roux-en-Y gastric bypass surgery (RYGB). However, studies on S100A8/A9 and the pathophysiological mechanisms in insulin resistance and diabetes are few and contradictory.
We studied 48 subjects who underwent RYGB, comprising a non-diabetic control group and two diabetic groups in whom diabetes either regressed or persisted, 6-12 months post-surgically. S100A8/A9, interleukin 6 (IL-6) as well as other inflammatory and diabetes-related markers were measured pre- and post-surgically.
Significant and similar decreases of BMI were found in all groups. S100A8/A9 and IL-6 decreased significantly in the group with diabetes remission and in the control group, but not in the group with persistent diabetes. The relative changes in S100A8/A9 and IL-6 correlated significantly (r = 0.905, p = 0.005) only in the group with persistent diabetes. In contrast, leukocyte count and C-reactive protein correlated significantly to S100A8/A9 only in the control group.
Our study is suggestive of S100A8/A9 and IL-6 being related to a persistent diabetes status post-surgically and of different pathophysiological mechanisms being involved in the post-surgical changes in the three groups, despite similar decreases in BMI.
肥胖是胰岛素抵抗和糖尿病的主要促成因素，在肥胖状态下，S100A8/A9（钙卫蛋白）的循环水平升高，而在 Roux-en-Y 胃旁路手术（RYGB）后下降。然而，关于 S100A8/A9 以及胰岛素抵抗和糖尿病的病理生理机制的研究较少且相互矛盾。
我们研究了 48 名接受 RYGB 的受试者，包括一个非糖尿病对照组和两个糖尿病组，其中糖尿病在术后 6 - 12 个月时要么缓解要么持续存在。在手术前后测量了 S100A8/A9、白细胞介素 6（IL - 6）以及其他炎症和糖尿病相关标志物。
所有组的 BMI 均显著且相似地下降。S100A8/A9 和 IL - 6 在糖尿病缓解组和对照组中显著下降，但在糖尿病持续组中未下降。仅在糖尿病持续组中，S100A8/A9 和 IL - 6 的相对变化显著相关（r = 0.905，p = 0.005）。相反，仅在对照组中，白细胞计数和 C 反应蛋白与 S100A8/A9 显著相关。
我们的研究表明，S100A8/A9 和 IL - 6 与术后糖尿病持续状态有关，并且尽管三组的 BMI 下降相似，但三组术后变化涉及不同的病理生理机制。
