Sulcebe Genc, Shyti Erkena
Laboratory of Immunology and Histocompatibility, University of Medicine, Tirana and University Hospital Center "Mother Teresa", Tirana, Albania.
Laboratory of Immunology and Histocompatibility, University of Medicine, Tirana and University Hospital Center "Mother Teresa", Tirana, Albania.
Hum Immunol. 2016 Aug;77(8):620-621. doi: 10.1016/j.humimm.2016.06.001. Epub 2016 Jun 2.
This paper reports the HLA-A, -B, -C, -DRB1 and -DQB1 allele and haplotype polymorphism in a population of 432 healthy individuals from Albania. First-field HLA genotyping was performed by polymerase chain reaction sequence-specific priming and/or oligonucleotide methods. The data were analyzed statistically using gene counting and Arlequin software packages. No deviation from Hardy Weinberg Equilibrium was detected at any of the loci studied. The HLA genotypic data of the population sample reported here are available publicly in the Allele Frequencies Net Database and they can serve as a reference database for further HLA-based population genetics studies including the Albanian population.
本文报道了来自阿尔巴尼亚的432名健康个体群体中HLA - A、- B、- C、- DRB1和 - DQB1等位基因及单倍型多态性。通过聚合酶链反应序列特异性引物和/或寡核苷酸方法进行HLA第一字段基因分型。使用基因计数和Arlequin软件包对数据进行统计分析。在所研究的任何基因座均未检测到偏离哈迪 - 温伯格平衡的情况。本文报道的群体样本的HLA基因型数据可在等位基因频率网络数据库中公开获取,它们可作为进一步基于HLA的群体遗传学研究(包括阿尔巴尼亚人群体)的参考数据库。