Kuzminova Elena, Khamaganova Ekaterina, Gaponova Tatiana, Savchenko Valeriy
Research Center for Hematology, Novy Zykovsky proezd 4, Moscow, 125167, Russian Federation.
Research Center for Hematology, Novy Zykovsky proezd 4, Moscow, 125167, Russian Federation.
Hum Immunol. 2018 Oct;79(10):709-710. doi: 10.1016/j.humimm.2018.07.231. Epub 2018 Aug 3.
This report shows the HLA-A, -B, -C, -DRB1 and -DQB1 allele and haplotype frequencies in a population of 127 healthy Ossetian donors of blood marrow from Vladikavkaz, Russia. First- and second-field (for HLA-C locus) HLA genotyping was performed by polymerase chain reaction sequence-specific priming and/or oligonucleotide probes. Statistical analysis were performed using gene counting and Arlequin software packages. There was no deviation from Hardy-Weinberg equilibrium for all tested loci. The HLA genotypic and haplotypic data of the Ossetians reported here are available in free access at the Allele Frequencies Net Database (http://www.allelefrequencies.net). This data can serve as a reference database for further HLA-based studies in population genetics.
本报告展示了来自俄罗斯弗拉季高加索的127名健康奥塞梯骨髓捐献者群体中的HLA - A、- B、- C、- DRB1和 - DQB1等位基因及单倍型频率。通过聚合酶链反应序列特异性引物和/或寡核苷酸探针进行了第一和第二领域（针对HLA - C位点）的HLA基因分型。使用基因计数和Arlequin软件包进行统计分析。所有测试位点均未偏离哈迪 - 温伯格平衡。此处报告的奥塞梯人的HLA基因型和单倍型数据可在等位基因频率网络数据库（http://www.allelefrequencies.net）免费获取。该数据可作为群体遗传学中进一步基于HLA研究的参考数据库。
