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马来半岛 194 例东南亚华人的 HLA-A、-B、-C、-DRB1 和-DQB1 等位基因和单倍型。

HLA-A, -B, -C, -DRB1 and -DQB1 alleles and haplotypes in 194 Southeast Asia Chinese from Peninsular Malaysia.

机构信息

Allergy and Immunology Research Center, Institute for Medical Research, Ministry of Health Malaysia, Kuala Lumpur, Malaysia; Department of Medicine, Division of Rheumatology, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden.

Allergy and Immunology Research Center, Institute for Medical Research, Ministry of Health Malaysia, Kuala Lumpur, Malaysia.

出版信息

Hum Immunol. 2019 Nov;80(11):906-907. doi: 10.1016/j.humimm.2019.09.005. Epub 2019 Sep 23.

DOI:10.1016/j.humimm.2019.09.005
PMID:31558331
Abstract

A total of 194 Southeast Asia Chinese from Peninsular Malaysia were genotyped for HLA-A, -B, -C -DRB1, and -DQB1 loci using polymerase chain reaction sequence-specific oligonucleotide probe hybridization methods. In this report, the HLA-B, HLA-DRB1 and HLA-DQB1 were in Hardy-Weinberg proportions (HWEP) (p > 0.05). We observed significant deviation from HWEP in HLA-A (p < 0.05) and HLA-C (p < 0.01) loci. This genotype data was available in Allele Frequencies Network Database (AFND) Dos Santos et al. (2016).

摘要

共对来自马来西亚半岛的 194 名东南亚华人进行了 HLA-A、-B、-C-DRB1 和-DQB1 基因座的聚合酶链反应序列特异性寡核苷酸探针杂交方法基因分型。在本报告中，HLA-B、HLA-DRB1 和 HLA-DQB1 处于哈迪-温伯格平衡（HWEP）（p>0.05）。我们观察到 HLA-A（p<0.05）和 HLA-C（p<0.01）基因座与 HWEP 显著偏离。该基因型数据可在 Allele Frequencies Network Database (AFND) Dos Santos 等人的研究中获得（2016 年）。

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