肥胖与双相情感障碍之间的潜在关联：一项荟萃分析。
The potential association between obesity and bipolar disorder: A meta-analysis.
作者信息
Zhao Zhuoxian, Okusaga Olaoluwa O, Quevedo Joao, Soares Jair C, Teixeira Antonio L
机构信息
Translational Psychiatry Program, Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston (UTHealth), Houston, TX, USA; University of Texas Harris County Psychiatric Center, 2800 South MacGregor Way, Houston, TX 77021, USA.
University of Texas Harris County Psychiatric Center, 2800 South MacGregor Way, Houston, TX 77021, USA.
出版信息
J Affect Disord. 2016 Sep 15;202:120-3. doi: 10.1016/j.jad.2016.05.059. Epub 2016 May 28.
BACKGROUND
Several epidemiological studies have found that the prevalence of bipolar disorder (BD) is significantly higher in obese population than non-obese population. However, no meta-analysis has been published to quantitatively summarize the related literature.
METHODS
In this study, we conducted a meta-analysis to explore the association between obesity and BD by combining 9 cross-sectional studies with a total of 12,259 BD cases and 615,490 non-BD controls. The meta-analysis was performed using the effect estimates and 95% confidence intervals (CIs) to calculate the pooled odds ratio (OR), while the heterogeneity was assessed using I(2) and Q statistic.
RESULTS
Our meta-analysis suggests that obesity is associated with increased prevalence of BD by a random-effect model (OR=1.77, 95% CI: 1.40-2.23; Q=44.62, P<0.001, I(2)=82.1%).
LIMITATION
Without prospective studies, we cannot determine whether obesity increased the risk of developing BD or vice-versa.
CONCLUSION
Obesity is positively associated with BD.
背景
多项流行病学研究发现，双相情感障碍（BD）在肥胖人群中的患病率显著高于非肥胖人群。然而，尚未发表荟萃分析来定量总结相关文献。
方法
在本研究中，我们进行了一项荟萃分析，通过合并9项横断面研究（共12259例BD病例和615490例非BD对照）来探讨肥胖与BD之间的关联。使用效应估计值和95%置信区间（CI）进行荟萃分析以计算合并比值比（OR），同时使用I²和Q统计量评估异质性。
结果
我们的荟萃分析表明，采用随机效应模型时，肥胖与BD患病率增加相关（OR = 1.77，95% CI：1.40 - 2.23；Q = 44.62，P < 0.001，I² = 82.1%）。
局限性
由于缺乏前瞻性研究，我们无法确定是肥胖增加了患BD的风险，还是反之。
结论
肥胖与BD呈正相关。
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