Esme Pelin, Botsali Aysenur
Department of Dermatology and Venereology, University of Health Sciences, Gulhane Training and Research Hospital, Ankara, Turkey.
Dermatol Pract Concept. 2022 Oct 1;12(4):e2022208. doi: 10.5826/dpc.1204a208. eCollection 2022 Nov.
Hidradenitis suppurativa (HS) is a chronic inflammatory skin disorder of the hair follicle characterized by intense discharge and pain. Recently, HS intrinsic association with neuropsychiatric disorders has become a focus of attention, and bipolar disorder (BD) emerged as a relevant topic for such an association.
This study aimed to evaluate BD prevalence among HS patients and present the HS and BD overlap patients demographics, detailed clinical characteristics with a discussion on aggravating factors.
A retrospective chart review of 247 HS outpatients (Group-1) identified nine patients with BD. The frequency of BD in HS patients is compared to psoriasis patients (Group-2) and controls (Group-3) in age- and gender-matched groups. The demographic and clinical features of the 9 patients revealing HS-BD co-existence were analyzed.
BD (N = 9) was the 7 most common co-morbidity in the HS cohort. The frequency of BD is detected as 3.6% in group 1, 0.7% (N = 1) in group 2, and 0.6% (N = 1) in group 3, respectively. Group 1 demonstrated an increased prevalence of BD compared to other groups (P = 0.001). Of the 9 patients revealing HS and BD co-existence, 66.6% were active smokers, 66.6% were obese and 44.4 % had metabolic syndrome.
This study results reveal that the prevalence of BD in HS patients is higher than psoriasis patients and controls. The pathogenetic mechanisms underlying BD and HS co-existence needs to be investigated further.
化脓性汗腺炎（HS）是一种毛囊慢性炎症性皮肤病，其特征为大量排液和疼痛。最近，HS与神经精神疾病的内在关联已成为关注焦点，双相情感障碍（BD）作为这种关联的一个相关话题出现。
本研究旨在评估HS患者中BD的患病率，并呈现HS与BD重叠患者的人口统计学特征、详细临床特征，并讨论加重因素。
对247例HS门诊患者（第1组）进行回顾性病历审查，确定9例BD患者。将HS患者中BD的发生率与年龄和性别匹配组的银屑病患者（第2组）和对照组（第3组）进行比较。分析9例显示HS与BD共存患者的人口统计学和临床特征。
BD（n = 9）是HS队列中第7常见的共病。第1组中BD的发生率分别为3.6%，第2组为0.7%（n = 1），第3组为0.6%（n = 1）。与其他组相比，第1组显示BD患病率增加（P = 0.001）。在9例显示HS与BD共存的患者中，66.6%为现吸烟者，66.6%肥胖，44.4%患有代谢综合征。
本研究结果显示，HS患者中BD的患病率高于银屑病患者和对照组。BD与HS共存的发病机制需要进一步研究。
