Alberding N, Frauenfelder H, Hänggi P
Proc Natl Acad Sci U S A. 1978 Jan;75(1):26-9. doi: 10.1073/pnas.75.1.26.
When ligand binding to proteins involves the presence of more than one ligand inside a given biomolecule, linear deterministic rate equations become useless. A stochastic approach, however, permits a treatment of the migration and binding of small molecules to proteins even at high ligand concentrations. An appropriate linear master equation and its analytic solution are given. As an example, the binding of carbon monoxide to myoglobin at partial pressures from 1 to 10(3) bars (0.1 to 100 MPa) is treated.
当配体与蛋白质的结合涉及给定生物分子内存在多个配体时，线性确定性速率方程就变得无用了。然而，一种随机方法允许处理小分子向蛋白质的迁移和结合，即使在高配体浓度下也是如此。给出了一个合适的线性主方程及其解析解。作为一个例子，处理了一氧化碳在1至10³巴（0.1至100兆帕）分压下与肌红蛋白的结合。
