一名急性髓系白血病M2型患者出现髓系前体细胞吞噬红细胞的噬血细胞综合征。

Hemophagocytic syndrome with erythrocyte phagocytosis by the myeloid precursors in a patient with AML -M2.

作者信息

Yılmaz Mümtaz, Vural Filiz, Töbü Mahmut, Ertan Yeşim, Büyük Filiz

出版信息

Turk J Haematol. 2008 Mar 5;25(1):42-4.

Abstract

Hemophagocytic syndrome is characterized by fever, fatigue, weight loss, lymphadenopathy, and laboratory abnormalities including pancytopenia, liver dysfunction, hypertriglyceridemia and hyperfibrinemia. Histopathologically, lesions are characterized by mononuclear cell infiltration with marked histiocyte proliferation and phagocytosis of erythrocytes, leukocytes, platelets and their precursors by activated macrophages in the reticuloendothelial tissues. Hemophagocytic syndrome may develop from strong immunological stimuli such as severe infection, malignancy and autoimmune diseases. We present a 73-year-old man with acute myeloblastic leukemia FAB M2 type (AML M2) whose bone marrow histology showed unusual hemophagocytosis by myeloid cells and myeloblasts.

摘要

噬血细胞综合征的特征为发热、乏力、体重减轻、淋巴结病以及实验室异常，包括全血细胞减少、肝功能障碍、高甘油三酯血症和高纤维蛋白血症。组织病理学上，病变的特征是单核细胞浸润，伴有明显的组织细胞增殖，以及网状内皮组织中活化巨噬细胞对红细胞、白细胞、血小板及其前体的吞噬作用。噬血细胞综合征可能由严重感染、恶性肿瘤和自身免疫性疾病等强烈免疫刺激引发。我们报告一例73岁男性急性髓系白血病FAB M2型（AML M2）患者，其骨髓组织学显示髓细胞和成髓细胞出现异常噬血现象。