Rademaker C M, van Dijk A, de Vries M H, Kadir F, Glerum J H
Department of Hospital Pharmacy, University Hospital Utrecht, the Netherlands.
Pharm Weekbl Sci. 1989 Apr 28;11(2):56-60. doi: 10.1007/BF01962976.
A practical, ready-to-use preparation of activated charcoal (AZU mixture) for application in toxicology has been formulated. To establish its efficacy, the formulation was tested in vitro and in dogs. The in vitro adsorption capacity was compared to that of freshly prepared charcoal suspension in water (CW) and to Carbomix. Langmuir adsorption coefficients demonstrated small but clinically insignificant differences in adsorption capacity between the preparations. The laxative sodium sulfate did not reduce the adsorption capacity of charcoal in vitro. Dogs were given 60 mg of paracetamol per kg as an oral solution followed by 5 g of activated charcoal preparation. The area under the plasma concentration versus time curve (control 2955 +/- 353 mg.min-1.l-1) was significantly reduced following CW (921 +/- 453) and AZU (786 +/- 270). The premixed AZU charcoal formulation is efficacious, inexpensive and overcomes the problems of bed-side preparation. An isolated vascularly perfused rat small intestine can be used to describe the effect of activated charcoal on the intestinal secretion of theophylline.
已配制出一种实用的、即用型的用于毒理学的活性炭制剂（AZU混合物）。为确定其疗效，该制剂在体外和犬类中进行了测试。将其体外吸附能力与新鲜制备的水中活性炭悬浮液（CW）以及Carbomix的吸附能力进行了比较。朗缪尔吸附系数表明，各制剂之间的吸附能力存在微小但临床上无显著意义的差异。泻药硫酸钠在体外并未降低活性炭的吸附能力。给犬口服每千克60毫克对乙酰氨基酚溶液，随后给予5克活性炭制剂。给予CW（921 +/- 453）和AZU（786 +/- 270）后，血浆浓度-时间曲线下面积（对照组为2955 +/- 353毫克·分钟-1·升-1）显著降低。预混合的AZU活性炭制剂有效、廉价且克服了床边配制的问题。分离的血管灌注大鼠小肠可用于描述活性炭对茶碱肠道分泌的影响。
