Berlinger W G, Spector R, Goldberg M J, Johnson G F, Quee C K, Berg M J
Clin Pharmacol Ther. 1983 Mar;33(3):351-4. doi: 10.1038/clpt.1983.44.
A randomized crossover trial of the effect of oral activated charcoal on the kinetics of intravenous theophylline was carried out in six normal male subjects. After intravenous aminophylline (6 mg/kg), subjects received water or water with activated charcoal (140 gm) in divided doses over 12 hr. Serum theophylline concentrations were measured from 0 to 24 hr after the aminophylline infusion. Treatment with activated charcoal decreased the serum t 1/2 from 6.4 +/- 1.2 to 3.3 +/- 0.4 (SEM) hr and the serum AUC from 78 +/- 14 to 42 +/- 4 mg . hr/l. Percent decrease in AUC after treatment with charcoal correlated positively with the endogenous theophylline serum t 1/2 (r = 0.94). These results suggest that oral activated charcoal (1) enhanced the total body clearance of theophylline and (2) may be efficacious in the treatment of theophylline poisoning, especially in patients with prolonged serum t 1/2s of theophylline.
在6名正常男性受试者中进行了一项关于口服活性炭对静脉注射茶碱动力学影响的随机交叉试验。静脉注射氨茶碱（6毫克/千克）后，受试者在12小时内分剂量服用水或含活性炭（140克）的水。在氨茶碱输注后0至24小时测量血清茶碱浓度。活性炭治疗使血清t1/2从6.4±1.2小时降至3.3±0.4（标准误）小时，血清AUC从78±14降至42±4毫克·小时/升。活性炭治疗后AUC的降低百分比与内源性茶碱血清t1/2呈正相关（r = 0.94）。这些结果表明，口服活性炭（1）提高了茶碱的全身清除率，（2）可能对茶碱中毒治疗有效，尤其是在茶碱血清t1/2延长的患者中。
