Visscher M O, Burkes S A, Adams D M, Gupta A, Wickett R R
Skin Sciences Program, Division of Plastic Surgery, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Skin Res Technol. 2016 Nov;22(4):487-496. doi: 10.1111/srt.12290. Epub 2016 Jun 5.
Infantile hemangiomas (IHs) are benign vascular neoplasms with rapid capillary proliferation shortly after birth and slow involution with diminishing capillary proliferative activity, fibrosis, and fatty replacement over 7-10 years.
Hemangiomas and contralateral control sites in 88 subjects were measured using a suction device, 6-mm probe and 200 mbar negative pressure. Mechanical properties were assessed vs. controls and effects of body site, depth, clinical stage, histology diagnosis, and time.
Biological elasticity, overall elasticity, net elasticity, total recovery, and elastic recovery were lower for IH vs. controls (P < 0.001). IH total deformation, elastic deformation, viscoelastic creep, and residual deformation were higher than controls (P < 0.001). Involuting IHs had lower viscoelasticity than proliferating and stable lesions (P < 0.001) and lower viscoelastic creep than stable IHs (P = 0.04). IH viscoelasticity was higher at 2.3 than 12.9, 23.7, and 61.0 months and at 4.9 and 8.1 than 61.0 months. IH elastic recovery varied by body site with larger differences vs. control for abdomen and leg. Elastic recovery differences from control were smaller at younger vs. older ages.
Measurement of biomechanical properties may be useful to characterize IH progression and treatment response in clinical settings.
婴儿血管瘤（IHs）是一种良性血管肿瘤，出生后不久毛细血管迅速增殖，随后在7至10年的时间里随着毛细血管增殖活性、纤维化和脂肪替代的减少而缓慢消退。
使用抽吸装置、6毫米探头和200毫巴负压对88名受试者的血管瘤及对侧对照部位进行测量。评估其力学性能，并与对照组进行比较，同时分析身体部位、深度、临床分期、组织学诊断和时间的影响。
与对照组相比，婴儿血管瘤的生物弹性、总体弹性、净弹性、总恢复率和弹性恢复率较低（P < 0.001）。婴儿血管瘤的总变形、弹性变形、粘弹性蠕变和残余变形高于对照组（P < 0.001）。消退期婴儿血管瘤的粘弹性低于增殖期和稳定期病变（P < 0.001），且粘弹性蠕变低于稳定期婴儿血管瘤（P = 0.04）。婴儿血管瘤在2.3个月时的粘弹性高于12.9、23.7和61.0个月时，在4.9和8.1个月时高于61.0个月时。婴儿血管瘤的弹性恢复因身体部位而异，腹部和腿部与对照组的差异更大。与对照组相比，弹性恢复差异在较年轻年龄组比在较年长年龄组更小。
生物力学性能的测量可能有助于在临床环境中表征婴儿血管瘤的进展和治疗反应。
