Murray B C, Wickett R R
University of Cincinnati College of Pharmacy, Cincinnati, Ohio, USA.
Skin Res Technol. 1997 May;3(2):101-6. doi: 10.1111/j.1600-0846.1997.tb00170.x.
BACKGROUND/AIMS: The Dermal Torque Meter® (DTM) and the Cutometer® are instruments that measure mechanical properties of skin. The NOVA(tm) Dermal Phase Meter® (DPM) measures the stratum corneum (SC) hydration level. The objectives of this study were to determine which parameters of the DTM data curves were most sensitive to changes in SC hydration level, which of the two instruments (Cutometer or DTM) was most sensitive, and what correlations existed between the Cutometer and DTM data.
Dry leg skin was created on nine subjects by washing with soap and using no moisturizers for one week. The skin was then treated with moisturizing lotions for two weeks. Measurements were made with the Cutometer, DTM, and DPM pre- and post-treatment.
Significant changes in DPM, DTM, and Cutometer measurements were found after the moisturizer treatment. However, correlations were not found between mechanical property data and DPM data. The DTM had the two parameters with the highest sensitivity of all of the DTM and Cutometer parameters. Finally, correlations between the two instruments existed for only three of the ten parameters investigated.
While measurements with all three instruments significantly changed in response to skin hydration, neither the DTM nor Cutometer data tended to correlate with DPM data, perhaps due to the differences in the depths into the skin which each instrument measures. Furthermore, the mechanical properties measured by the two instruments do not correlate well between the instruments. Finally, the DTM was found to have the most sensitive parameters.
背景/目的：皮肤扭矩测量仪（DTM）和皮肤弹性测定仪是用于测量皮肤机械性能的仪器。新型皮肤相位测量仪（DPM）可测量角质层（SC）的水合水平。本研究的目的是确定DTM数据曲线的哪些参数对SC水合水平的变化最敏感，两种仪器（皮肤弹性测定仪或DTM）中哪一种最敏感，以及皮肤弹性测定仪和DTM数据之间存在何种相关性。
对9名受试者的腿部皮肤进行处理，先用肥皂清洗，一周内不使用保湿剂，从而制造出干燥皮肤。然后用保湿乳液对皮肤进行两周的治疗。在治疗前后分别使用皮肤弹性测定仪、DTM和DPM进行测量。
保湿剂治疗后，DPM、DTM和皮肤弹性测定仪的测量结果有显著变化。然而，在机械性能数据和DPM数据之间未发现相关性。在DTM和皮肤弹性测定仪的所有参数中，DTM有两个参数的敏感性最高。最后，在所研究的10个参数中，两种仪器之间仅在3个参数上存在相关性。
虽然使用这三种仪器进行的测量都因皮肤水合作用而发生了显著变化，但DTM和皮肤弹性测定仪的数据都与DPM数据没有相关性，这可能是由于每种仪器测量的皮肤深度不同所致。此外，两种仪器测量的机械性能在仪器之间的相关性也不佳。最后，发现DTM具有最敏感的参数。
