Kim Han-Joon, Kim Yong-Ku
Department of Psychiatry,College of Medicine,Korea University,Seoul,Republic of Korea.
Acta Neuropsychiatr. 2016 Dec;28(6):357-361. doi: 10.1017/neu.2016.25. Epub 2016 Jun 6.
Immune system activation is involved in the pathophysiology of panic disorder (PD). We investigated INF-γ+874 A/T, TNF-α-308 G/A, and IL-10-1082 G/A single nucleotide polymorphisms (SNPs) to determine their association with PD.
This study enroled 135 PD patients and 135 healthy controls. INF-γ+874 A/T (rs2430561), TNF-α-308 G/A (rs1800629), and IL-10-1082 G/A (rs1800896) were genotyped.
There were no differences in genotypes or allele frequencies between the patient and control groups, regardless of accompanying agoraphobia. However, for female patients, the G allele frequency in IL-10 SNP was higher in the control group than in the patient group. Additionally, the female control group had a higher frequency of the A/G and G/G genotype in the IL-10 SNP than the female patient group.
We suggest that the G allele in IL-10-1082 G/A might have a role in reducing the manifestations of PD in female patients. Further studies are needed to extend and confirm our findings.
免疫系统激活参与惊恐障碍（PD）的病理生理学过程。我们研究了INF-γ+874 A/T、TNF-α-308 G/A和IL-10-1082 G/A单核苷酸多态性（SNP），以确定它们与PD的关联。
本研究纳入了135例PD患者和135例健康对照。对INF-γ+874 A/T（rs2430561）、TNF-α-308 G/A（rs1800629）和IL-10-1082 G/A（rs1800896）进行基因分型。
无论是否伴有广场恐惧症，患者组和对照组之间的基因型或等位基因频率均无差异。然而，对于女性患者，对照组中IL-10 SNP的G等位基因频率高于患者组。此外，女性对照组中IL-10 SNP的A/G和G/G基因型频率高于女性患者组。
我们认为IL-10-1082 G/A中的G等位基因可能在减轻女性患者PD的表现方面发挥作用。需要进一步的研究来扩展和证实我们的发现。
