Simoneau J A, Pette D
Fakultät für Biologie, Universität Konstanz, Federal Republic of Germany.
Pflugers Arch. 1989 Apr;413(6):679-81. doi: 10.1007/BF00581821.
Analyses of lactate dehydrogenase (LDH) isozymes were performed in normal and chronically stimulated (10 Hz, 10 h/d) tibialis anterior (TA) muscles of the mouse, rat, guinea pig, and rabbit. The electrophoretic mobilities of the individual LDH isozymes of normal muscles revealed species-specific patterns. Stimulation up to 28 days evoked increases in the percentage of the H-subunit of LDH. The absolute increase was highest in the rabbit, intermediate in the guinea pig and rat, and lowest in the mouse. The extent of the M- to H-subunit exchange, thus, appeared to be inversely correlated with the basal aerobic-oxidative capacities of the investigated muscles. In addition, a relationship between the expression of the H-subunit of LDH and the increase in aerobic-oxidative capacity became evident from these stimulation-induced processes of metabolic adaptation.
对小鼠、大鼠、豚鼠和兔子的正常及长期刺激（10赫兹，每天10小时）的胫前肌进行乳酸脱氢酶（LDH）同工酶分析。正常肌肉中各个LDH同工酶的电泳迁移率呈现出物种特异性模式。长达28天的刺激引起LDH的H亚基百分比增加。绝对增加量在兔子中最高，在豚鼠和大鼠中居中，在小鼠中最低。因此，M亚基到H亚基的交换程度似乎与所研究肌肉的基础有氧氧化能力呈负相关。此外，从这些刺激诱导的代谢适应过程中可以明显看出，LDH的H亚基表达与有氧氧化能力的增加之间存在关联。
