Shukla Arpana, Bansal Vivek, Bhutani Ritu, Kumar Gaurav, Sharma Jai, Solanki Surinder, Mehta Anurag
Rajiv Gandhi Cancer Institute and Research Centre, Department of Radiation Oncology, Sector V, Rohini 110085 Delhi, India Phone: 91-11-47022222 E-mail:
Turk J Haematol. 2011 Sep 5;28(3):228-31. doi: 10.5152/tjh.2011.59.
Extramedullary plasmacytoma (EMP) is a plasma cell neoplasm without bone marrow involvement or other systemic characteristics of multiple myeloma. Few large-scale clinical studies have been conducted because of the rarity of EMP, especially when it arises from the mediastinum. Herein we report a rare case of solitary mediastinal plasmacytoma with reactive pleural effusion. A 58-year-old female presented with grade 4 dyspnea and dysphagia, with a mediastinal mass observed with on PET. CT-guided biopsy results were suggestive of IgG kappa-type EMP arising from the anterior mediastinum. The patient was treated with local radiotherapy to the mediastinum, and had clinical and radiological response s were good. Radiotherapy is an effective treatment for mediastinal EMP, but a complete workup is mandatory, including PET, as the majority of such masses coexist with multiple myeloma.
髓外浆细胞瘤（EMP）是一种浆细胞肿瘤，不累及骨髓，也无多发性骨髓瘤的其他全身特征。由于EMP罕见，尤其是起源于纵隔时，很少有大规模临床研究。在此，我们报告一例罕见的伴有反应性胸腔积液的孤立性纵隔浆细胞瘤。一名58岁女性出现4级呼吸困难和吞咽困难，PET检查发现纵隔肿块。CT引导下活检结果提示为起源于前纵隔的IgG κ型EMP。患者接受了纵隔局部放疗，临床和影像学反应良好。放疗是纵隔EMP的有效治疗方法，但必须进行全面检查，包括PET，因为此类肿块大多与多发性骨髓瘤共存。
