Tarkun Pınar, Hacıhanefioğlu Abdullah, Demirbağ Emine, Turgut Tuğba
Turk J Haematol. 2005 Jun 5;22(2):95-9.
Drug induced autoimmune hemolytic anemia is a well-known complication of drug therapy but it is often misdiagnosed. Drug induced autoimmune hemolytic anemia is difficult to differantiate from classical autoimmune hemolytic anemia. Here, we have reported a case with autoimmune hemolytic anemia might be caused by drugs such as teicoplanin, imipenem and amphotericin B. In our case, on the fifteenth postadmission day was occur autoimmune hemolytic anemia. At this while, chemotherapy of patient had been completed and the patient have been taking antibiotherapy which include teicoplanin, imipenem and amphotericin B. Antibiotherapy could not be stopped because of febrile neutropenia. Symptoms and sings of anemia improved with prednisolon therapy. Suspicious drug must be stopped in drug induced autoimmune hemolytic anemia but in the conditions that drug could not be stopped, steroid treatment can be used in the treatment of hemolytic anemia.
药物性自身免疫性溶血性贫血是药物治疗中一种众所周知的并发症，但它常常被误诊。药物性自身免疫性溶血性贫血很难与经典的自身免疫性溶血性贫血相鉴别。在此，我们报告了一例自身免疫性溶血性贫血可能由替考拉宁、亚胺培南和两性霉素B等药物引起的病例。在我们的病例中，入院后第15天出现了自身免疫性溶血性贫血。此时，患者的化疗已经完成，并且一直在接受包括替考拉宁、亚胺培南和两性霉素B的抗菌治疗。由于发热性中性粒细胞减少症，抗菌治疗不能停止。使用泼尼松龙治疗后，贫血的症状和体征有所改善。在药物性自身免疫性溶血性贫血中，必须停用可疑药物，但在无法停药的情况下，类固醇治疗可用于溶血性贫血的治疗。
