Role of Progenitor Cells in Liver Regeneration after Subtotal Resection.
作者信息
El'chaninov A V, Fatkhudinov T Kh, Kananykhina E Yu, Usman N Yu, Arutyunyan I V, Makarov A V, Bykov A V, Bolshakova G V, Sukhikh G T
机构信息
V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation, Moscow, Russia.
Institute of Human Morphology, Moscow, Russia.
出版信息
Bull Exp Biol Med. 2016 May;161(1):155-61. doi: 10.1007/s10517-016-3367-5. Epub 2016 Jun 6.
In the liver of rats subjected to subtotal liver resection (80% organ weight), the expression of sox9 gene and SOX9 protein content increased and cells with hepatocyte morphology expressing SOX9 appeared; the proportion of cells expressing cytokeratin-19 also increased. Based on these data, we cannot completely exclude the involvement of resident progenitor cells and hepatocyte reprogramming in liver regeneration after subtotal resection, however, the contribution of these processes seems to be insignificant. The leading mechanism of liver mass recovery after subtotal resection is proliferation of hepatocytes.
Zotero 插件