Connexin 43 and CaV1.2 Ion Channel Trafficking in Healthy and Diseased Myocardium.
作者信息
Basheer Wassim A, Shaw Robin M
机构信息
From the Heart Institute and Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA (W.A.B., R.M.S.); and Department of Medicine, University of California Los Angeles (R.M.S.).
出版信息
Circ Arrhythm Electrophysiol. 2016 Jun;9(6):e001357. doi: 10.1161/CIRCEP.115.001357.
Abstract
摘要
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Circulation. 2016 Jan 26;133(4):388-97. doi: 10.1161/CIRCULATIONAHA.115.018535. Epub 2016 Jan 5.
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Cardiomyocyte-specific overexpression of the ubiquitin ligase Wwp1 contributes to reduction in Connexin 43 and arrhythmogenesis.泛素连接酶Wwp1在心肌细胞中的特异性过表达导致连接蛋白43减少并引发心律失常。
J Mol Cell Cardiol. 2015 Nov;88:1-13. doi: 10.1016/j.yjmcc.2015.09.004. Epub 2015 Sep 16.
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Connexin 43 is an emerging therapeutic target in ischemia/reperfusion injury, cardioprotection and neuroprotection.连接蛋白43是缺血/再灌注损伤、心脏保护和神经保护领域中一个新兴的治疗靶点。
Pharmacol Ther. 2015 Sep;153:90-106. doi: 10.1016/j.pharmthera.2015.06.005. Epub 2015 Jun 11.
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Heart ischemia results in connexin43 ubiquitination localized at the intercalated discs.心脏缺血导致连接蛋白43泛素化定位于闰盘。
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