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[自体巨噬细胞在肺结核合并非特异性支气管炎患者联合治疗中的应用]

[Autologous macrophages in combined therapy of patients with tuberculosis complicated by nonspecific bronchitis].

作者信息

Shesterina M V, Kalinina M V

出版信息

Probl Tuberk. 1989(3):22-5.

PMID:2726705
Abstract

The function of the lung macrophagal system was estimated in patients with pulmonary tuberculosis complicated by nonspecific inflammatory processes. A decrease in the absolute and relative contents of alveolar macrophages (AM) in bronchoalveolar lavage fluid (BALF) and their lower absorbing activity were revealed. Autologic macrophages from blood monocytes had higher functional activity than AM. Introduction of autologic macrophages into the bronchial tree in the patients with tuberculosis associated with catarrhal and purulent endobronchitis promoted normalization of the BALF cytograms, increasing AM activity and involution of the specific and nonspecific processes.

摘要

对合并非特异性炎症过程的肺结核患者的肺巨噬细胞系统功能进行了评估。结果显示,支气管肺泡灌洗液(BALF)中肺泡巨噬细胞(AM)的绝对含量和相对含量均降低,且其吞噬活性较低。来自血液单核细胞的自体巨噬细胞比AM具有更高的功能活性。将自体巨噬细胞引入伴有卡他性和化脓性细支气管炎的肺结核患者的支气管树中,可促进BALF细胞图谱正常化,提高AM活性,并使特异性和非特异性过程消退。

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