通过铑(III)催化双功能底物的 C-C/C-N 偶联反应获得结构多样的喹啉稠合杂环。
Access to Structurally Diverse Quinoline-Fused Heterocycles via Rhodium(III)-Catalyzed C-C/C-N Coupling of Bifunctional Substrates.
机构信息
Dalian Institute of Chemical Physics, Chinese Academy of Sciences , Dalian 116023, China.
出版信息
Org Lett. 2016 Jun 17;18(12):2812-5. doi: 10.1021/acs.orglett.6b01032. Epub 2016 Jun 7.
PMID:27267178
Abstract
Rhodium(III)-catalyzed C-H activation of heteroarenes and functionalization with bifunctional substrates such as anthranils allows facile construction of quinoline-fused heterocycles under redox-neutral conditions. The couplings feature broad substrate scope and provide step-economical access to two classes of quinoline-fused condensed heterocycles.
摘要
铑(III)催化杂芳烃的 C-H 活化以及与双功能底物（如邻苯二甲酰亚胺）的官能化反应，可在氧化还原中性条件下轻松构建喹啉稠合杂环。这些偶联反应具有广泛的底物范围，并为两类喹啉稠合稠合杂环提供了具有经济性的合成途径。
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