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1
Energy conformation study of Met-enkephalin and its D-Ala2 analogue and their resemblance to rigid opiates.甲硫氨酸脑啡肽及其D-丙氨酸2类似物的能量构象研究以及它们与刚性阿片类药物的相似性。
Proc Natl Acad Sci U S A. 1978 Jan;75(1):7-11. doi: 10.1073/pnas.75.1.7.
2
Structure-activity studies of narcotic agonists and antagonists from quantum chemical calculations.基于量子化学计算的麻醉性激动剂和拮抗剂的构效关系研究
NIDA Res Monogr. 1978(22):278-316.
3
Classification of multiple morphine and enkephalin binding sites in the central nervous system.中枢神经系统中多种吗啡和脑啡肽结合位点的分类
Proc Natl Acad Sci U S A. 1981 Oct;78(10):6181-5. doi: 10.1073/pnas.78.10.6181.
4
Conformational-energy studies of tetrapeptide opiates. Candidate active and inactive conformations.四肽类阿片药物的构象能研究。候选活性和非活性构象。
Mol Pharmacol. 1982 Nov;22(3):667-77.
5
Conformational energy calculations on enkephalins and enkephalin analogs. Classification of conformations to different configurational types.脑啡肽及脑啡肽类似物的构象能计算。构象对不同构型类型的分类。
Int J Pept Protein Res. 1981 Sep;18(3):256-75. doi: 10.1111/j.1399-3011.1981.tb02980.x.
6
Effect of D-alanine methionine enkephalin amide on ion transport in rabbit ileum.D-丙氨酸甲硫氨酸脑啡肽酰胺对兔回肠离子转运的影响。
J Clin Invest. 1980 Jul;66(1):19-28. doi: 10.1172/JCI109830.
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Possible role of distinct morphine and enkephalin receptors in mediating actins of benzomorphan drugs (putative kappa and sigma agonists).不同的吗啡和脑啡肽受体在介导苯并吗啡烷类药物（假定的κ和σ激动剂）作用中的可能作用。
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Geometrical correspondence between phenazocine and the enkephalins.非那佐辛与脑啡肽之间的几何对应关系。
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10
Selective protection of stereospecific enkephalin and opiate binding against inactivation by N-ethylmaleimide: evidence for two classes of opiate receptors.立体特异性脑啡肽和阿片类物质结合对N-乙基马来酰亚胺失活的选择性保护：两类阿片受体的证据。
Proc Natl Acad Sci U S A. 1980 Jan;77(1):281-4. doi: 10.1073/pnas.77.1.281.

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Supraspinal peroxynitrite modulates pain signaling by suppressing the endogenous opioid pathway.脊髓以上的过氧亚硝酸盐通过抑制内源性阿片途径来调节疼痛信号。
J Neurosci. 2012 Aug 8;32(32):10797-808. doi: 10.1523/JNEUROSCI.6345-11.2012.
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Stereochemical basis for a unified structure activity theory of aromatic and heterocyclic rings in selected opioids and opioid peptides.某些阿片类药物和阿片肽中芳香环与杂环统一构效关系理论的立体化学基础
Perspect Medicin Chem. 2010 Feb 18;4:1-10. doi: 10.4137/pmc.s3898.
3
To the problem of biologically active conformation of enkephalin.针对脑啡肽生物活性构象的问题。
Mol Cell Biochem. 1981 Jan 20;34(1):23-9. doi: 10.1007/BF02354848.
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X-ray diffraction studies of enkephalins. Crystal structure of [(4'-bromo) Phe4,Leu5]enkephalin.脑啡肽的X射线衍射研究。[(4'-溴)苯丙氨酸4，亮氨酸5]脑啡肽的晶体结构。
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Molecular-dynamics simulations of [Met5]- and [D-Ala2,Met5]-enkephalins. Biological implication of monomeric folded and dimeric unfolded conformations.[Met5]-脑啡肽和[D-Ala2,Met5]-脑啡肽的分子动力学模拟。单体折叠构象和二聚体未折叠构象的生物学意义。
Biochem J. 1988 Oct 15;255(2):621-8.
6
Conformation-activity relationships of opiate analgesics.阿片类镇痛药的构效关系。
J Comput Aided Mol Des. 1987 Apr;1(1):53-72. doi: 10.1007/BF01680557.
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Synthesis and conformational analysis of a series of galactosyl enkephalin analogues showing high analgesic activity.一系列显示出高镇痛活性的半乳糖基脑啡肽类似物的合成与构象分析
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9
A proposal for the molecular basis of mu and delta opiate receptor differentiation based on modeling of two types of cyclic enkephalins and a narcotic alkaloid.基于两种环脑啡肽和一种麻醉性生物碱的模型对μ和δ阿片受体分化分子基础的提议。
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10
Characterization of low-energy conformational domains for Met-enkephalin.甲硫氨酸脑啡肽低能量构象域的表征
J Comput Aided Mol Des. 1992 Apr;6(2):175-90. doi: 10.1007/BF00129427.

本文引用的文献

1
Stereochemical criteria for polypeptides and proteins. V. Conformation of a system of three linked peptide units.多肽和蛋白质的立体化学标准。V. 三个相连肽单元系统的构象
Biopolymers. 1968 Oct;6(10):1425-36. doi: 10.1002/bip.1968.360061006.
2
Conformation of the LL and LD hairpin bends with internal hydrogen bonds in proteins and peptides.蛋白质和肽中具有内部氢键的LL和LD发夹弯曲结构。
Biochim Biophys Acta. 1973 Mar 23;303(1):14-27. doi: 10.1016/0005-2795(73)90143-8.
3
Molecular orbital calculations on the conformation of nucleic acids and their constituents. VI. Conformation about the exocyclic C(4')-C(5') bond in alpha-nucleosides.核酸及其成分构象的分子轨道计算。VI. α-核苷中外环C(4')-C(5')键的构象
Biochim Biophys Acta. 1973 Apr 11;299(4):497-9. doi: 10.1016/0005-2787(73)90220-7.
4
Isolation and structure identification of a morphine-like peptide "enkephalin" in bovine brain.牛脑中一种类吗啡肽“脑啡肽”的分离与结构鉴定。
Life Sci. 1976 Apr 15;18(8):781-7. doi: 10.1016/0024-3205(76)90002-3.
5
A morphine-like factor 'enkephalin' in rat brain: subcellular localization.大鼠脑中一种类似吗啡的因子“脑啡肽”：亚细胞定位
Brain Res. 1976 May 14;107(3):650-7. doi: 10.1016/0006-8993(76)90155-4.
6
Structural and conformational relationships between the enkephalins and the opiates.脑啡肽与阿片类药物之间的结构和构象关系。
Nature. 1976 Apr 29;260(5554):795-7. doi: 10.1038/260795a0.
7
Analgesia induced in vivo by central administration of enkephalin in rat.大鼠体内通过脑室内注射脑啡肽诱导产生的镇痛作用。
Nature. 1976 Apr 15;260(5552):625-6. doi: 10.1038/260625a0.
8
Biosynthetic origin and receptor conformation of methionine enkephalin.甲硫氨酸脑啡肽的生物合成起源与受体构象
Nature. 1976 Mar 11;260(5547):165-6. doi: 10.1038/260165a0.
9
Energetics of folding of a lysozyme beta-bend.溶菌酶β-转角折叠的能量学
J Mol Biol. 1975 Mar 15;92(4):567-72. doi: 10.1016/0022-2836(75)90310-1.
10
Purification and properties of enkephalin - the possible endogenous ligand for the morphine receptor.脑啡肽的纯化及其性质——吗啡受体可能的内源性配体
Life Sci. 1975 Jun 15;16(12):1753-8. doi: 10.1016/0024-3205(75)90268-4.

甲硫氨酸脑啡肽及其D-丙氨酸2类似物的能量构象研究以及它们与刚性阿片类药物的相似性。

Energy conformation study of Met-enkephalin and its D-Ala2 analogue and their resemblance to rigid opiates.

作者信息

Loew G H, Burt S K

出版信息

Proc Natl Acad Sci U S A. 1978 Jan;75(1):7-11. doi: 10.1073/pnas.75.1.7.

DOI:10.1073/pnas.75.1.7
PMID:272674
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC411171/
Abstract

Conformational similarities of Met-enkephalin and its D-Ala2 analogue to rigid opiates were studied by both empirical and quantum mechanical methods. By both methods, conformers with maximum resemblance to rigid opiates have the highest energies. Conformers with the lowest energy had no resemblance to rigid opiates. However, several low and intermediate energy conformers were identified in which at least the NH2-terminal tyrosine residue overlaps with the phenethylamine moiety of rigid opiates and which could equally well accommodate either Gly2 or D-Ala2. The conformer among these with greatest additional resemblance to other binding sites of rigid opiates is proposed as the most likely candidate for an induced fit at the receptor site.

摘要

采用经验方法和量子力学方法研究了甲硫氨酸脑啡肽及其D-丙氨酸2类似物与刚性阿片类药物的构象相似性。通过这两种方法，与刚性阿片类药物相似度最高的构象体能量最高。能量最低的构象体与刚性阿片类药物没有相似之处。然而，鉴定出了几种低能量和中等能量的构象体，其中至少NH2末端酪氨酸残基与刚性阿片类药物的苯乙胺部分重叠，并且可以同样好地容纳Gly2或D-Ala2。这些构象体中与刚性阿片类药物其他结合位点额外相似度最高的构象体被认为是受体位点诱导契合的最可能候选者。