Department of Health, National Institute for Health and Welfare (THL), Helsinki, Finland.
Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.
Psychiatry Res. 2016 Aug 30;242:101-110. doi: 10.1016/j.psychres.2016.05.044. Epub 2016 May 30.
Cryptochromes are key components of the circadian clocks that generate and maintain seasonal variations. The aim of our study was to analyze the associations of CRY1 and CRY2 genetic variants with the problematicity of seasonal variations, and whether the problematicity of seasonal variations changed during the follow-up of 11 years. Altogether 21 CRY1 and 16 CRY2 single-nucleotide polymorphisms (SNPs) were genotyped and analyzed in 5910 individuals from a Finnish nationwide population-based sample who had filled in the self-report on the seasonal variations in mood and behavior in the year 2000. In the year 2011, 3356 of these individuals filled in the same self-report on the seasonal variations in mood and behavior. Regression models were used to test whether any of the SNPs associated with the problematicity of seasonal variations or with a change in the problematicity from 2000 to 2011. In the longitudinal analysis, CRY2 SNP rs61884508 was protective from worsening of problematicity of seasonal variations. In the cross-sectional analysis, CRY2 SNP rs72902437 showed evidence of association with problematicity of seasonal variations, as did SNP rs1554338 (in the MAPK8IP1 and downstream of CRY2).
隐花色素是生物钟的关键组成部分，生物钟产生并维持季节性变化。我们的研究目的是分析 CRY1 和 CRY2 基因变异与季节性变化问题的相关性，以及季节性变化问题是否在 11 年的随访过程中发生变化。总共对来自芬兰全国基于人群的样本中的 5910 名个体的 21 个 CRY1 和 16 个 CRY2 单核苷酸多态性（SNP）进行了基因分型和分析，这些个体在 2000 年填写了关于情绪和行为季节性变化的自我报告。在 2011 年，这些个体中有 3356 人填写了关于情绪和行为季节性变化的相同自我报告。回归模型用于测试任何 SNP 是否与季节性变化问题的严重程度或从 2000 年到 2011 年的变化有关。在纵向分析中，CRY2 SNP rs61884508 对季节性变化问题的恶化具有保护作用。在横断面分析中，CRY2 SNP rs72902437 与季节性变化问题存在关联的证据，CRY2 基因下游的 SNP rs1554338（在 MAPK8IP1 中）也是如此。
