Toscano-Flores Liliana G, Jacinto-Méndez Damián, Carbajal-Tinoco Mauricio D
Departamento de Física, Centro de Investigación y de Estudios Avanzados del IPN , Apartado Postal 14-740, 07000 Cd. de México, Mexico.
J Phys Chem B. 2016 Jun 30;120(25):5655-61. doi: 10.1021/acs.jpcb.6b03983. Epub 2016 Jun 17.
We present a method to describe the formation of small lipid vesicles in terms of three bending elastic constants that can be experimentally measured. Our method combines a general expression of the elastic free energy of the bilayer and the thermodynamic description of molecular aggregation. The resulting model requires the size distribution of liposomes, which is determined from the X-ray scattered intensity spectra of vesicular dispersions. By using two different preparation methods, we studied a series of vesicular solutions made of distinct lipids and we obtained their corresponding bending elastic constants that are consistent with known bending rigidities.
我们提出了一种根据三个可通过实验测量的弯曲弹性常数来描述小脂质囊泡形成的方法。我们的方法结合了双层膜弹性自由能的一般表达式和分子聚集的热力学描述。所得模型需要脂质体的尺寸分布，该分布由囊泡分散体的X射线散射强度光谱确定。通过使用两种不同的制备方法，我们研究了一系列由不同脂质制成的囊泡溶液，并获得了与已知弯曲刚度一致的相应弯曲弹性常数。
