Lebedeva Yu A, Zakharova A V, Sitdikova G F, Zefirov A L, Khazipov R N
Kazan (Volga Region) Federal University, Kazan, Russia.
Mediterranean Institute of Neurobiology (INMED), Marseille, France.
Bull Exp Biol Med. 2016 May;161(1):15-9. doi: 10.1007/s10517-016-3334-1. Epub 2016 Jun 6.
The effects of general anesthetics ketamine and midazolam, the drugs that cause neuroapoptosis at the early stages of CNS development, on electrical activity of the somatosensory cortex in newborn rats were studied using extracellular recording of local field potentials and action potentials of cortical neurons. Combined administration of ketamine (40 mg/kg) and midazolam (9 mg/kg) induced surgical coma and almost completely suppressed early oscillatory patterns and neuronal firing. These effects persisted over 3 h after injection of the anesthetics. We concluded that general anesthesia induced by combined administration of ketamine and midazolam profoundly suppressed cortical activity in newborn rats, which can trigger neuroapoptosis in the developing brain.
使用细胞外记录局部场电位和皮质神经元动作电位的方法，研究了全身麻醉药氯胺酮和咪达唑仑（这两种药物在中枢神经系统发育早期会导致神经细胞凋亡）对新生大鼠体感皮层电活动的影响。氯胺酮（40毫克/千克）和咪达唑仑（9毫克/千克）联合给药会诱导手术昏迷，并几乎完全抑制早期振荡模式和神经元放电。这些效应在注射麻醉药后持续超过3小时。我们得出结论，氯胺酮和咪达唑仑联合给药诱导的全身麻醉会深刻抑制新生大鼠的皮层活动，这可能会触发发育中大脑的神经细胞凋亡。
