Chu Qinjun, Mao Meng, Bai Yafan, Sun Liwei, Zhang Dongqing, Zheng Ping, Jin Xiaogao
Department of Anesthesiology and Perioperative Medicine, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou, China.
West Houston Family Practice, Houston, TX, United States.
Front Vet Sci. 2022 Apr 11;9:829747. doi: 10.3389/fvets.2022.829747. eCollection 2022.
Esketamine showed more potency, more rapid recovery from anesthesia, and less psychotomimetic side effects when compared with ketamine. However, the patients still experience psychotomimetic side effects of esketamine. In order to investigate whether midazolam can attenuate the esketamine-induced overactive behaviors and neuronal hyperactivities, midazolam 0, 40, 80, and 120 mg/kg combined with esketamine 50 mg/kg were administrated on Kunming mice to assess the behaviors changes during anesthesia. The indicators, including action time, duration of agitation before the sedation, duration of sedation, duration of loss of pedal withdrawal reaction (PWR), duration of loss of righting reaction (RR), duration of agitation during the recovery, and recovery time, were monitored for up to 3-4 h after intraperitoneal administration. The results demonstrated that midazolam 40, 80, and 120 mg/kg efficiently decreased the esketamine-induced overactive behaviors including ataxia, excitation, and catalepsy before sedation. Midazolam and esketamine synergically improved the anesthesia quality assessed by PWR and RR. However, even high doses of midazolam were not able to suppress the esketamine-induced psychotomimetic effects during the recovery.
与氯胺酮相比，艾司氯胺酮显示出更强的效力、更快的麻醉恢复速度以及更少的拟精神病副作用。然而，患者仍会经历艾司氯胺酮的拟精神病副作用。为了研究咪达唑仑是否能减轻艾司氯胺酮诱导的过度活跃行为和神经元活动亢进，将0、40、80和120mg/kg的咪达唑仑与50mg/kg的艾司氯胺酮联合给予昆明小鼠，以评估麻醉期间的行为变化。在腹腔注射后长达3-4小时内监测包括行动时间、镇静前躁动持续时间、镇静持续时间、足趾退缩反应（PWR）消失持续时间、翻正反射（RR）消失持续时间、恢复期间躁动持续时间和恢复时间等指标。结果表明，40、80和120mg/kg的咪达唑仑有效降低了艾司氯胺酮诱导的包括共济失调、兴奋和镇静前僵住等过度活跃行为。咪达唑仑和艾司氯胺酮协同改善了通过PWR和RR评估的麻醉质量。然而，即使是高剂量的咪达唑仑也无法抑制恢复期间艾司氯胺酮诱导的拟精神病效应。
