Megwalu Uchechukwu C, Green Ross W
Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA, U.S.A.
Department of Otolaryngology-Head and Neck Surgery, Icahn School of Medicine at Mount Sinai, New York, NY, U.S.A.
Anticancer Res. 2016 Jun;36(6):2899-902.
To compare the effectiveness of total thyroidectomy versus thyroid lobectomy for the treatment of follicular thyroid microcarcinoma.
Data were extracted from the Surveillance, Epidemiology, and End Results 18 Database. The study cohort included patients diagnosed with follicular thyroid microcarcinoma between 1988 and 2009, treated with either total thyroidectomy or thyroid lobectomy. Propensity-score analysis using inverse probability weighting was used to control for allocation bias.
A total of 203 patients were identified. The 5-year overall survival was 98% for patients treated with lobectomy and 99% for those treated with total thyroidectomy; this difference was not statistically significant (p=0.13). Unadjusted analysis and propensity-score analysis revealed no difference in overall survival between the two treatment groups (p=0.15 and p=0.49, respectively).
Total thyroidectomy does not appear to offer any survival advantage over thyroid lobectomy for patients with follicular thyroid microcarcinoma.
比较全甲状腺切除术与甲状腺叶切除术治疗甲状腺微小滤泡癌的有效性。
数据取自监测、流行病学与最终结果18数据库。研究队列包括1988年至2009年间诊断为甲状腺微小滤泡癌且接受全甲状腺切除术或甲状腺叶切除术治疗的患者。采用逆概率加权法进行倾向评分分析以控制分配偏倚。
共识别出203例患者。接受叶切除术患者的5年总生存率为98%，接受全甲状腺切除术患者的5年总生存率为99%；此差异无统计学意义（p = 0.13）。未调整分析和倾向评分分析显示，两个治疗组的总生存率无差异（分别为p = 0.15和p = 0.49）。
对于甲状腺微小滤泡癌患者，全甲状腺切除术似乎并不比甲状腺叶切除术具有任何生存优势。
