Boonrod Arunnit, Akkus Zeynettin, Castro M Regina, Zeinodini Atefeh, Philbrick Kenneth, Stan Marius, Erickson Dana, Erickson Bradley
Department of Radiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
Radiology Informatics Lab, Department of Radiology, Mayo Clinic, Rochester, MN, USA.
Asian Pac J Cancer Prev. 2021 Aug 1;22(8):2597-2602. doi: 10.31557/APJCP.2021.22.8.2597.
The management of follicular (FN) and Hurthle cell neoplasms (HCN) is often difficult because of the uncertainty of malignancy risk. We aimed to assess characteristics of benign and malignant follicular and Hurthle neoplasms based on their shape and size.
Patients with Follicular adenoma (FA) or carcinoma (FC) and Hurthle Cell adenoma (HCA) or carcinoma (HCC) who had preoperative ultrasonography were included. Demographic data were retrieved. Size and shape of the nodules were measured. Logistic regression analyses and odds ratios were performed.
A total of 115 nodules with 57 carcinomas and 58 adenomas were included. Logistic regression analysis shows that the nodule height and the patient age are predictors of malignancy (p-values = 0.001 and 0.042). A cutoff value of nodule height ≥ 4 cm. produces an odds ratio of 4.5 (p-value = 0.006). An age ≥ 55 year-old demonstrates an odds ratio of 2.4-3.6 (p-value = 0.03). Taller-than-wide shape was not statistically significant (p-value = 0.613).
FC and HCC are larger than FA and HCA in size, with a cutoff at 4 cm. Increasing age increases the odds of malignancy with a cutoff at 55 year-old. Taller-than-wide shape is not a predictor of malignancy.
由于恶性风险的不确定性，滤泡性肿瘤（FN）和许特耳细胞瘤（HCN）的管理通常很困难。我们旨在根据其形状和大小评估良性和恶性滤泡性及许特耳肿瘤的特征。
纳入术前进行过超声检查的滤泡性腺瘤（FA）或癌（FC）以及许特耳细胞腺瘤（HCA）或癌（HCC）患者。检索人口统计学数据。测量结节的大小和形状。进行逻辑回归分析和比值比计算。
共纳入115个结节，其中57个为癌，58个为腺瘤。逻辑回归分析表明，结节高度和患者年龄是恶性肿瘤的预测因素（p值分别为0.001和0.042）。结节高度≥4 cm的截断值产生的比值比为4.5（p值 = 0.006）。年龄≥55岁的比值比为2.4 - 3.6（p值 = 0.03）。高宽比形状无统计学意义（p值 = 0.613）。
FC和HCC在大小上大于FA和HCA，截断值为4 cm。年龄增加会增加恶性肿瘤的几率，截断值为55岁。高宽比形状不是恶性肿瘤的预测因素。
