Hu Jie, Rivero Fernando, Torres Rio Aguilar, Loro Ramírez Héctor, Rodríguez Emma Martín, Alfonso Fernando, García Solé José, Jaque Daniel
Fluorescence Imaging Group, Departamento de Física de Materiales, Instituto Nicolás Cabrera, Facultad de Ciencias, Universidad Autónoma de Madrid, 28049, Madrid, Spain.
Cardiology Department, Hospital Universitario de la Princesa, IIS-IP, Universidad Autónoma de Madrid, Madrid.
J Biophotonics. 2017 May;10(5):674-682. doi: 10.1002/jbio.201600062. Epub 2016 Jun 8.
The potential use of Gold Nanoparticles (GNPs) as contrast agents for clinical intracoronary frequency domain Optical Coherence Tomography (OCT) is here explored. The OCT contrast enhancement caused by GNPs of different sizes and morphologies has been systematically investigated and correlated with their optical properties. Among the different GNPs commercially available with plasmon resonances close to the operating wavelength of intracoronary OCT (1.3 µm), Gold Nanoshells (GNSs) have provided the best OCT contrast due to their largest scattering cross section at this wavelength. Clinical intracoronary OCT catheters are here demonstrated to be capable of three dimensional visualization and real-time tracking of individual GNSs. Results here included open an avenue to novel application of intravascular clinical OCT in combination with GNPs, such as real time evaluation of intravascular obstructions or pressure gradients.
本文探讨了金纳米颗粒（GNP）作为临床冠状动脉内频域光学相干断层扫描（OCT）造影剂的潜在用途。系统研究了不同尺寸和形态的GNP引起的OCT对比度增强，并将其与光学特性相关联。在商业上可获得的具有接近冠状动脉内OCT工作波长（1.3μm）的等离子体共振的不同GNP中，金纳米壳（GNS）由于在此波长下具有最大的散射截面，提供了最佳的OCT对比度。本文证明临床冠状动脉内OCT导管能够对单个GNS进行三维可视化和实时跟踪。本文的结果为血管内临床OCT与GNP结合的新应用开辟了道路，例如血管内阻塞或压力梯度的实时评估。
