Inhibition of glyoxalase I by new squaric acid derivatives.
作者信息
Kraus J L, Castaing M
机构信息
Laboratoire de Chimie Biomoléculaire - Faculté des Sciences de Luminy Case 901, Marseille.
出版信息
Res Commun Chem Pathol Pharmacol. 1989 Mar;63(3):467-70.
PMID:2727397
Abstract
Synthesis and antiglyoxalase activity of new squaric acid derivatives have been studied. It has been established that the substitution of one hydroxyl group of the squaric acid (1,2-dihydroxy cyclobutene 3,4-dione) by an N-substituted group decreased the antiglyoxalase activity while the corresponding - 2 methoxy substituted derivatives were comparatively equipotent.
摘要
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