Yao Mengzhu, Sheng Xiaoxia, Lin Jun, Gao Jianqing
Institute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
Hangzhou Solipharma Co. Ltd, Hangzhou 310058,China.
Zhejiang Da Xue Xue Bao Yi Xue Ban. 2016 Mar;45(2):161-9. doi: 10.3785/j.issn.1008-9292.2016.03.09.
Carbon nanotubes possess excellent mechanical and electrical properties and demonstrate broad application prospects in medical fields. Carbon nanotubes are composed of inorganic materials, natural biodegradable polymer or synthetic biodegradable polymer. The composite bone tissue engineering scaffolds are constructed by particle-hole method, lyophilization, microsphere aggregation method, electrostatic spinning or three-dimensional printing. Composite scaffolds overcome the shortcomings of single material and have good biocompatibility, osteoconduction and osteoinduction. With the study of surface chemistry, toxicology, and biocompatibility, a degradable "human-friendly" carbon nanotubes composite bone tissue scaffold will be available; and under the drive of new fabrication techniques, the clinical application of carbon nanotubes composite bone tissue engineering scaffolds will be better developed.
碳纳米管具有优异的机械和电学性能，在医学领域展现出广阔的应用前景。碳纳米管由无机材料、天然可生物降解聚合物或合成可生物降解聚合物组成。复合骨组织工程支架通过颗粒-孔隙法、冻干法、微球聚集法、静电纺丝或三维打印构建而成。复合支架克服了单一材料的缺点，具有良好的生物相容性、骨传导性和骨诱导性。随着表面化学、毒理学和生物相容性研究的深入，一种可降解的“亲人体”碳纳米管复合骨组织支架将会问世；并且在新型制造技术的推动下，碳纳米管复合骨组织工程支架的临床应用将会得到更好的发展。
