Laojaroenwanit Sittikorn, Layanun Vimontip, Praneeprachachon Pokpong, Pukrushpan Parnchat
Department of Ophthalmology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Clin Ophthalmol. 2016 May 18;10:897-902. doi: 10.2147/OPTH.S102611. eCollection 2016.
We aimed to 1) determine the time of maximum cycloplegia after instillation of cyclopentolate 1% in children with brown irises, 2) evaluate the correlation between the pupillary reaction and time of maximum cycloplegia, and 3) identify any side effects of the medication.
This was a prospective analytical study involving children aged 5 to 14 years who were attending refraction clinic. Cyclopentolate 1% was instilled three times at 10-minute intervals. The spherical equivalent, pupillary reaction, and pupillary diameter were recorded before the first drop and nine times after the last drop at 10-minute intervals. Side effects were assessed. Time of maximum cycloplegia was determined from the time point at which the 95% confidence interval of the differences between the mean spherical equivalent at each point and its final value at 110 minutes was reached and remained within the equivalence limit (±0.25 D).
Sixty children were enrolled in this study. Their mean age was 9.8 years (range: 5-4 years). Time of maximum cycloplegia was reached at 30 minutes after the first instillation of cyclopentolate. A poor correlation was observed between the pupillary reaction and the time of maximum cycloplegia (r=-0.07). The mean pupillary diameter at 30 minutes was 3.7±1.3 mm, and further dilation occurred thereafter. No side effects were observed.
In most children, maximum cycloplegia was reached 30 minutes after the first instillation of cyclopentolate. The absence of a pupillary reaction should not be used as an indicator of maximum cycloplegia.
我们旨在1）确定在患有棕色虹膜的儿童中滴入1%环喷托酯后最大睫状肌麻痹的时间，2）评估瞳孔反应与最大睫状肌麻痹时间之间的相关性，以及3）确定该药物的任何副作用。
这是一项前瞻性分析研究，纳入了5至14岁在验光诊所就诊的儿童。每隔10分钟滴入1%环喷托酯3次。在第一滴药前以及最后一滴药后每隔10分钟记录9次等效球镜度、瞳孔反应和瞳孔直径。评估副作用。最大睫状肌麻痹时间是根据每个时间点的平均等效球镜度与其在110分钟时的最终值之间差异的95%置信区间达到并保持在等效限度（±0.25 D）内的时间点来确定的。
本研究纳入了60名儿童。他们的平均年龄为9.8岁（范围：5 - 14岁）。在首次滴入环喷托酯后30分钟达到最大睫状肌麻痹时间。观察到瞳孔反应与最大睫状肌麻痹时间之间的相关性较差（r = -0.07）。30分钟时的平均瞳孔直径为3.7±1.3 mm，此后瞳孔进一步散大。未观察到副作用。
在大多数儿童中，首次滴入环喷托酯后30分钟达到最大睫状肌麻痹。不应将瞳孔反应消失用作最大睫状肌麻痹的指标。
