Bagheri A, Givrad S, Yazdani S, Reza Mohebbi M
Department of Ophthalmology and Ophthalmic Research Center, Labbafinejad Hospital, Shaheed Beheshti University of Medical Science, Tehran, Iran.
Eur J Ophthalmol. 2007 May-Jun;17(3):294-300. doi: 10.1177/112067210701700303.
To determine the optimal dosage of cyclopentolate for adequate cycloplegia with minimal side effects.
A prospective randomized clinical trial of patients 3.5 to 20 years of age referred to a strabismus clinic during a 1-year period. Eligible patients were randomly divided into three groups. In Group 1, the cycloplegic effect of one drop of cyclopentolate was compared with two drops; in Group 2, the effect of two drops was compared with three drops; and in Group 3, the effect of one drop was compared with three drops.
This study includes 192 eyes of 96 patients with a mean age of 11.0 +/- 5.7 years. Strabismus was present in 43 patients (44.8%). A total of 146 patients (76%) were hyperopic, 33 (17.2%) were myopic, and 13 (6.8%) were slightly hyperopic or myopic at the two stages of the study. Overall, only 16 eyes, including 9 eyes in Group 1 (16.4%), 2 eyes in Group 2 (3.2%), and 5 eyes in Group 3 (8.6%), had > or = 0.5 D difference in spherical equivalent refractive error at two stages of the study; however, intergroup differences were not statistically significant (p=0.16, chi-square test). Within each group, the percentage of eyes with <0.5 D difference was significantly greater than those with > or = 0.5 D difference (p<0.001 in all three groups, binomial test). Side effects were more prevalent using more frequent drops.
A single drop of cyclopentolate 1% suffices for cycloplegic refraction. There were less frequent side effects using one drop of cyclopentolate, compared to two or three drops.
确定能产生充分睫状肌麻痹且副作用最小的环喷托酯最佳剂量。
一项针对1年内转诊至斜视门诊的3.5至20岁患者的前瞻性随机临床试验。符合条件的患者被随机分为三组。在第1组中，比较一滴环喷托酯与两滴环喷托酯的睫状肌麻痹效果；在第2组中，比较两滴与三滴的效果；在第3组中，比较一滴与三滴的效果。
本研究纳入了96例患者的192只眼，平均年龄为11.0±5.7岁。43例患者（44.8%）存在斜视。在研究的两个阶段，共有146例患者（76%）为远视，33例（17.2%）为近视，13例（6.8%）为轻度远视或近视。总体而言，在研究的两个阶段，仅16只眼，包括第1组中的9只眼（16.4%）、第2组中的2只眼（3.2%）和第3组中的5只眼（8.6%），球镜等效屈光不正差异≥0.5 D；然而，组间差异无统计学意义（p = 0.16，卡方检验）。在每组中，球镜等效屈光不正差异<0.5 D的眼的百分比显著高于差异≥0.5 D的眼（所有三组中p<0.001，二项式检验）。使用滴数更多时副作用更常见。
1%的环喷托酯一滴足以用于睫状肌麻痹验光。与两滴或三滴相比，使用一滴环喷托酯时副作用较少。
