Ljungström I, van Knapen F
Department of Parasitology, National Bacteriological Laboratory, Stockholm, Sweden.
Scand J Infect Dis. 1989;21(1):87-93. doi: 10.3109/00365548909035685.
The serological prevalence of toxocara infection was determined in 323 sera from statistically selected healthy individuals from different geographical areas of Sweden. The serological response in 175 sera from patients suspected of having contracted toxocariasis was compared with their clinical manifestation and age. The sera were analysed by ELISA using excretory/secretory antigens. The serological prevalence in young adults was estimated to 7%, indicating that subclinical toxocariasis occurs in healthy Swedes. The prevalence figure is not contrasting with reports from other countries. Antibodies were predominantly demonstrated in sera from men living in a rural community compared to sera from the other areas investigated (p less than 0.01). 91% of the sera from patients were obtained from patients greater than 5 years old. The clinical manifestations were ocular disorder (46%), eosinophilia (32%), lung, liver, neurological disorders (14%). The disorders were equally distributed between the age groups. A seropositive reaction was noted in 25% of the patients and the various clinical manifestations and age groups were equally represented among the seropositives. However, the percentage of seropositive patients with ocular disorders increased with growing age, whereas the opposite was observed in patients with eosinophilia. The results indicate that clinically apparent toxocariasis exists in Sweden.
在从瑞典不同地理区域随机选取的323名健康个体的血清样本中，测定了弓蛔虫感染的血清学流行率。将175名疑似感染弓蛔虫病患者的血清学反应与其临床表现和年龄进行了比较。采用排泄/分泌抗原，通过酶联免疫吸附测定（ELISA）法对血清进行分析。结果显示，年轻成年人的血清学流行率估计为7%，这表明健康的瑞典人中存在亚临床型弓蛔虫病。这一流行率数据与其他国家的报告并无差异。与其他调查地区的血清相比，来自农村社区男性的血清中抗体检出率更高（p值小于0.01）。91%的患者血清样本来自年龄大于5岁的患者。临床表现包括眼部疾病（46%）、嗜酸性粒细胞增多（32%）、肺部、肝脏和神经系统疾病（14%）。这些疾病在各年龄组中分布均衡。25%的患者出现血清学阳性反应，血清学阳性患者中的各种临床表现和年龄组分布也较为均衡。然而，血清学阳性且患有眼部疾病的患者比例随年龄增长而增加，而嗜酸性粒细胞增多患者的情况则相反。结果表明，瑞典存在临床症状明显的弓蛔虫病。
