El-Shazly Atef M, Abdel Baset S M, Kamal A, Mohammed Khairy A, Sakrs T I, Hammad S M
Department of Parasitology, Faculty of Medicine, Mansoura University, Egypt.
J Egypt Soc Parasitol. 2009 Dec;39(3):731-44.
A total of 455 patients who fulfilled the inclusion criteria were included in the study. The enrolled patients were subjected to a questionnaire (including sociodemographic and other risk factors) and thorough clinical examination was done for the patients. Sera were collected from patients and tested for anti-Toxocara IgG antibodies using ELISA. The overall anti- Toxocara seropositive was (7.7%). It was significantly higher than among the randomly selected 30 healthy controls. There were no significant differences between the seropositive and seronegative patients regarding age, sex, educational level and monthly family income of the patient. However, rural residence, poor house, pet's ownership and frequent contact with soil were found to be significant. Patients who had confirmed bronchial asthma were more than 2 times at higher risk of developing toxocariasis (OR, 2.33; 95% CI, 1.09-4.98) than those with other clinical diagnosis (PUO, hepatomegaly or heptosplenomegaly, lymphadenopathy, neurological disorders, gastrointestinal troubles and dermatitis). Patients with eosinophilia were at 149 times greater risk of being Toxocara seropositive compared to those without eosinophilia (OR, 148.7; 95% CI: 53.5-413.3). Multivariate regression analysis showed eosinophilia and contact with soil were the most important predictors of toxocariasis. OD of anti-Toxocara antibodies (ELISA) was significantly positive with eosinophilia level.
共有455名符合纳入标准的患者被纳入研究。对入选患者进行了问卷调查（包括社会人口统计学和其他风险因素），并对患者进行了全面的临床检查。采集患者血清，采用酶联免疫吸附测定法检测抗弓蛔虫免疫球蛋白G抗体。抗弓蛔虫血清学总体阳性率为7.7%。该阳性率显著高于随机选择的30名健康对照者。血清阳性和血清阴性患者在年龄、性别、教育水平和患者家庭月收入方面无显著差异。然而，农村居住、住房条件差、拥有宠物和经常接触土壤被发现具有显著性。确诊为支气管哮喘的患者患弓蛔虫病的风险比其他临床诊断（不明原因发热、肝肿大或肝脾肿大、淋巴结病、神经系统疾病、胃肠道疾病和皮炎）的患者高2倍多（比值比，2.33；95%置信区间，1.09 - 4.98）。与无嗜酸性粒细胞增多症的患者相比，嗜酸性粒细胞增多症患者抗弓蛔虫血清阳性的风险高149倍（比值比，148.7；95%置信区间：53.5 - 413.3）。多因素回归分析显示，嗜酸性粒细胞增多症和接触土壤是弓蛔虫病最重要的预测因素。抗弓蛔虫抗体（酶联免疫吸附测定法）的光密度与嗜酸性粒细胞增多水平呈显著正相关。
