在单一中心对特发性炎性肌病患者进行大腿磁共振成像以评估疾病活动度。
Thigh magnetic resonance imaging for the evaluation of disease activity in patients with idiopathic inflammatory myopathies followed in a single center.
作者信息
Barsotti Simone, Zampa Virna, Talarico Rosaria, Minichilli Fabrizio, Ortori Simona, Iacopetti Valentina, D'ascanio Anna, Tavoni Antonio Gaetano, Bombardieri Stefano, Mosca Marta, Neri Rossella
机构信息
Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
Genetic, Oncology and Clinical Medicine doctorate, University of Siena, Siena, Italy.
出版信息
Muscle Nerve. 2016 Oct;54(4):666-72. doi: 10.1002/mus.25099. Epub 2016 Jun 9.
INTRODUCTION
In patients with idiopathic inflammatory myopathies (IIM), magnetic resonance imaging (MRI) has been proposed as a useful tool for diagnosis and follow-up. It may identify muscle inflammation (edema) and fatty infiltration for evaluation of disease activity and damage. Little information is available on the role of MRI in assessment of large cohorts of adult patients with IIM.
METHODS
Fifty-one patients underwent MRI of the thigh muscles, laboratory tests, and clinical evaluation, including Physician Global Assessment (PGA) of myositis activity and the Manual Muscle Test 8 (MMT8).
RESULTS
Muscle edema correlated significantly with creatine kinase values (P = 0.017) and PGA (P < 0.001). A significant correlation between edema and MMT8 values (P = 0.025) was observed when patients with muscle fatty infiltration were excluded. With respect to clinical diagnosis, the sensitivity of MRI was 92.3%, and specificity was 83.3%.
CONCLUSIONS
MRI appears to provide additional information that complements clinical and biochemical examinations. Muscle Nerve 54: 666-672, 2016.
引言
在特发性炎性肌病（IIM）患者中，磁共振成像（MRI）已被视为诊断和随访的有用工具。它可以识别肌肉炎症（水肿）和脂肪浸润，以评估疾病活动和损伤情况。关于MRI在评估大量成年IIM患者中的作用，目前所知甚少。
方法
51例患者接受了大腿肌肉MRI检查、实验室检查以及临床评估，包括肌炎活动度的医师整体评估（PGA）和徒手肌力测试8级（MMT8）。
结果
肌肉水肿与肌酸激酶值（P = 0.017）和PGA（P < 0.001）显著相关。排除肌肉脂肪浸润患者后，观察到水肿与MMT8值之间存在显著相关性（P = 0.025）。就临床诊断而言，MRI的敏感性为92.3%，特异性为83.3%。
结论
MRI似乎能提供补充临床和生化检查的额外信息。《肌肉与神经》54: 666 - 672, 2016年。
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