Li Wei, Luo Songyuan, Luo Jianfang, Liu Yuan, Huang Wenhui, Chen Jiyan
Department of Cardiology, Southern Medical University, Guangzhou, People's Republic of China; Department of Cardiology, Guangdong Provincial Cardiovascular Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, People's Republic of China.
Department of Cardiology, Guangdong Provincial Cardiovascular Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, People's Republic of China.
Clin Interv Aging. 2016 May 19;11:683-8. doi: 10.2147/CIA.S104425. eCollection 2016.
Currently, the association between abdominal aortic plaques and coronary artery disease (CAD) has not yet been clarified clearly. The purpose of this study was to determine the prevalence of abdominal aortic plaques by ultrasound imaging and to explore its association with CAD in patients undergoing coronary angiography.
Between October 2014 and June 2015, a prospective study was conducted in the Department of Cardiology at Guangdong General Hospital, Guangzhou, People's Republic of China. Ultrasound scanning of the abdominal aortas was performed in 1,667 consecutive patients undergoing coronary angiography. Clinical characteristics and coronary profile were collected from the patients.
Of the 1,667 study patients (male, 68.9%; mean age, 63±11 years) undergoing coronary angiography, 1,268 had CAD. Compared with 399 patients without CAD, 1,268 patients with CAD had higher prevalence of abdominal aortic plaques (37.3% vs 17%, P<0.001). In multivariate analysis, abdominal aortic plaques served as independent factors associated with the presence of CAD (odds ratio =2.08; 95% confidence interval =1.50-2.90; P<0.001). Of the 1,268 patients with CAD, the prevalence of abdominal aortic plaques was 27.0% (98/363) in patients with one-vessel disease, 35.0% (107/306) in patients with two-vessel disease, and 44.7% (268/599) in patients with three-vessel disease. Stepwise increases in the prevalence of abdominal aortic plaque was found depending on the number of stenotic coronary vessels (P<0.001; P-value for trend <0.001). In an ordinal logistic regression model, abdominal aortic plaques served as independent factors associated with the severity of CAD according to the number of stenotic coronary vessels (P<0.001).
The prevalence of abdominal aortic plaques was higher in patients with CAD than in those without CAD. Abdominal aortic plaque was an independent factor associated with the presence and severity of CAD.
目前，腹主动脉斑块与冠状动脉疾病（CAD）之间的关联尚未完全明确。本研究旨在通过超声成像确定腹主动脉斑块的患病率，并探讨其与接受冠状动脉造影患者CAD的关联。
2014年10月至2015年6月，在中国广州广东省人民医院心内科进行了一项前瞻性研究。对1667例连续接受冠状动脉造影的患者进行腹主动脉超声扫描。收集患者的临床特征和冠状动脉情况。
在1667例接受冠状动脉造影的研究患者中（男性占68.9%；平均年龄63±11岁），1268例患有CAD。与399例无CAD的患者相比，1268例CAD患者腹主动脉斑块的患病率更高（37.3%对17%，P<0.001）。多因素分析中，腹主动脉斑块是与CAD存在相关的独立因素（比值比=2.08；95%置信区间=1.50-2.90；P<0.001）。在1268例CAD患者中，单支血管病变患者腹主动脉斑块的患病率为27.0%（98/363），双支血管病变患者为35.0%（107/306），三支血管病变患者为44.7%（268/599）。发现腹主动脉斑块的患病率根据狭窄冠状动脉血管的数量呈逐步增加（P<0.001；趋势P值<0.001）。在有序逻辑回归模型中，根据狭窄冠状动脉血管的数量，腹主动脉斑块是与CAD严重程度相关的独立因素（P<0.001）。
CAD患者腹主动脉斑块的患病率高于无CAD患者。腹主动脉斑块是与CAD的存在和严重程度相关的独立因素。
