Department of Periodontology Xiangya Stomatological Hospital Central South University Changsha, 410008, China
Med Oral Patol Oral Cir Bucal. 2022 Nov 1;27(6):e578-e587. doi: 10.4317/medoral.25514.
Coronary artery disease (CAD) is defined as one of the most common cardiovascular diseases (CVDs). Periodontitis is one of the risk factors for CAD.
PubMed, Embase and Cochrane Library databases were carefully and thoroughly retrieved until October 2021. On the basis of the inclusion and exclusion criteria, eligible articles were selected strictly to identify randomized controlled trials (RCTs). Using Cochran's Q statistic, Review Manager 5.4 and Stata 16, data were extracted, and a comprehensive analysis was carried out.
Six RCTs of 619 patients were included in this study, including 360 in the intervention group (IG) and 259 in the control group (CG). Meta-analysis showed significant difference for C-reactive protein (CRP) (1.20mg/L, 95% CI: 1.13 to 1.27, p < 0.00001) after non-surgical periodontal therapy (NSPT), but showed no significant difference for interleukin-6 (IL-6) (1.19mg/L, 95% CI: -1.03 to 3.40, p=0.29), flow-mediated dilation (FMD) (-1.64%, 95% CI: -4.95 to 1.67, p=0.33), triacylglycerol (TG) (-0.02mg/dL, 95% CI: -0.31 to 0.27, p=0.90), total cholesterol (TC) (0.04mg/dL, 95% CI: -0.25 to 0.33, p=0.90), low-density lipoprotein cholesterol (LDL-C) (0.00mg/dL, 95% CI: -0.29 to 0.29, p=0.99) and high-density lipoprotein cholesterol (HDL-C) (0.11mg/dL, 95% CI: -0.18 to 0.40, p=0.46).
The impact of NSPT on the reduction of CRP in patients of CAD with periodontitis is significant. NSPT can be considered as an important preventive strategy for major cardiovascular events in CAD.
冠心病（CAD）被定义为最常见的心血管疾病（CVDs）之一。牙周炎是 CAD 的一个危险因素。
仔细、彻底地检索了 PubMed、Embase 和 Cochrane Library 数据库，直到 2021 年 10 月。基于纳入和排除标准，严格选择符合条件的文章以确定随机对照试验（RCTs）。使用 Cochran's Q 统计量、Review Manager 5.4 和 Stata 16 提取数据，并进行综合分析。
本研究纳入了 6 项 RCT，共 619 例患者，其中干预组（IG）360 例，对照组（CG）259 例。Meta 分析显示，非手术牙周治疗（NSPT）后 C 反应蛋白（CRP）（1.20mg/L，95%CI：1.13-1.27，p<0.00001）有显著差异，但白细胞介素-6（IL-6）（1.19mg/L，95%CI：-1.03-3.40，p=0.29）、血流介导的扩张（FMD）（-1.64%，95%CI：-4.95-1.67，p=0.33）、三酰甘油（TG）（-0.02mg/dL，95%CI：-0.31-0.27，p=0.90）、总胆固醇（TC）（0.04mg/dL，95%CI：-0.25-0.33，p=0.90）、低密度脂蛋白胆固醇（LDL-C）（0.00mg/dL，95%CI：-0.29-0.29，p=0.99）和高密度脂蛋白胆固醇（HDL-C）（0.11mg/dL，95%CI：-0.18-0.40，p=0.46）无显著差异。
NSPT 可显著降低 CAD 合并牙周炎患者 CRP 水平，可作为 CAD 患者预防主要心血管事件的重要策略。
