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脊髓注射大麻素激动剂WIN 55,212-2对糖尿病大鼠热痛敏感性的影响。

The effect of spinally administered WIN 55,212-2, a cannabinoid agonist, on thermal pain sensitivity in diabetic rats.

作者信息

Jahanabadi Samane, Hadian Mohamad Reza, Shamsaee Javad, Tavangar Seyed Mohammad, Abdollahi Alireza, Dehpour Ahmadreza, Mehr Shahram Ejtemaei

机构信息

Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran; Faculty of Pharmacy, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

Department of Physical Therapy, Faculty of Rehabilitation Sciences, Tehran University of Medical Sciences, Tehran, Iran.

出版信息

Iran J Basic Med Sci. 2016 Apr;19(4):394-401.

PMID:27279983
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4887712/
Abstract

OBJECTIVES

Diabetic neuropathy (DN) is a common complication of diabetes that leads to allodynia, impaired nerve conduction, and progressive sensory loss. The aim of this study was to observe the effect of a high-affinity cannabinoid receptors agonist, WIN 55,212-2, on thermal hyperalgesia, nerve conduction velocity and sciatic nerve histopathology in diabetic rats.

MATERIALS AND METHODS

Diabetes was induced in rats using a single dose of streptozotocin (45 mg/kg IP).

RESULTS

Intrathecal (IT) administration of WIN55, 212-2 (1, 10, 100 µg/10 µl, IT), produced antinociceptive effects in the hot plate test and also improved nerve conduction velocity (100 µg/10 µl, IT) and sciatic nerve histology.

CONCLUSION

These data show that cannabinoids have potent antinociceptive effects through direct actions in the spinal dorsal horn of nociceptive pathway. This suggests that intrathecally administered cannabinoids may offer hopeful strategies for the treatment of diabetic neuropathic pain.

摘要

目的

糖尿病性神经病变（DN）是糖尿病常见的并发症，可导致痛觉过敏、神经传导受损及进行性感觉丧失。本研究旨在观察高亲和力大麻素受体激动剂WIN 55,212-2对糖尿病大鼠热痛觉过敏、神经传导速度及坐骨神经组织病理学的影响。

材料与方法

采用单剂量链脲佐菌素（45 mg/kg腹腔注射）诱导大鼠患糖尿病。

结果

鞘内注射WIN55,212-2（1、10、100 μg/10 μl，鞘内注射）在热板试验中产生抗伤害感受作用，还改善了神经传导速度（100 μg/10 μl，鞘内注射）及坐骨神经组织学。

结论

这些数据表明，大麻素通过在伤害性感受通路的脊髓背角直接发挥作用而具有强大的抗伤害感受作用。这表明鞘内注射大麻素可能为治疗糖尿病性神经病理性疼痛提供有希望的策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb32/4887712/fabc721c25fe/IJBMS-19-394-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb32/4887712/9f016d5a03dc/IJBMS-19-394-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb32/4887712/a8b6dc7d4a04/IJBMS-19-394-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb32/4887712/f5bed7075df9/IJBMS-19-394-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb32/4887712/53323dfc6a14/IJBMS-19-394-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb32/4887712/fabc721c25fe/IJBMS-19-394-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb32/4887712/9f016d5a03dc/IJBMS-19-394-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb32/4887712/a8b6dc7d4a04/IJBMS-19-394-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb32/4887712/f5bed7075df9/IJBMS-19-394-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb32/4887712/53323dfc6a14/IJBMS-19-394-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb32/4887712/fabc721c25fe/IJBMS-19-394-g006.jpg

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