Ingall T J, Whisnant J P, Wiebers D O, O'Fallon W M
Department of Neurology, Mayo Clinic, Rochester, Minnesota 55905.
Stroke. 1989 Jun;20(6):718-24. doi: 10.1161/01.str.20.6.718.
We studied subarachnoid hemorrhage in the population of Rochester, Minnesota, for the 40-year period from 1945 through 1984. The average annual incidence rate of subarachnoid hemorrhage in Rochester has remained constant at approximately 11 per 100,000 population. Age-specific incidence rates increased with age. However, the average annual mortality rate for subarachnoid hemorrhage in Rochester has shown a decreasing trend, from 6.8 per 100,000 population in 1955-1964 to 4.3 in 1975-1984. It is likely that this is due to a decrease in case-fatality rates from 57% in 1945-1974 to 42% in 1975-1984 (p = 0.10). This decreasing trend was also evident in annual mortality rates from subarachnoid hemorrhage for US white men and women. The reason for the improved case-fatality rate is unclear, but it may be related to changes in management. The interval from onset of subarachnoid hemorrhage to surgery decreased from a median of 12 days in 1975-1979 to 2 days in 1980-1984, and of those who survived to receive medical attention, more patients received some form of medical treatment in 1980-1984. Whether either or both of these changes have led to the decrease in the case-fatality rate is uncertain.
我们对明尼苏达州罗切斯特市1945年至1984年这40年间的蛛网膜下腔出血情况进行了研究。罗切斯特市蛛网膜下腔出血的年平均发病率一直保持稳定,约为每10万人中有11例。特定年龄发病率随年龄增长而上升。然而,罗切斯特市蛛网膜下腔出血的年平均死亡率呈下降趋势,从1955 - 1964年的每10万人中有6.8例降至1975 - 1984年的4.3例。这很可能是由于病死率从1945 - 1974年的57%降至1975 - 1984年的42%(p = 0.10)。这种下降趋势在美国白人男性和女性蛛网膜下腔出血的年死亡率中也很明显。病死率改善的原因尚不清楚,但可能与治疗管理的变化有关。蛛网膜下腔出血发作至手术的间隔时间从1975 - 1979年的中位数12天降至1980 - 1984年的2天,并且在存活并接受医疗救治的患者中,1980 - 1984年有更多患者接受了某种形式的治疗。这些变化中的一个或两个是否导致了病死率的下降尚不确定。