Babady N Esther
Clinical Microbiology Service, Department of Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA
J Clin Microbiol. 2016 Nov;54(11):2635-2646. doi: 10.1128/JCM.00604-16. Epub 2016 Jun 8.
Infections remain a significant cause of morbidity and mortality in cancer patients. The differential diagnosis for these patients is often wide, and the timely selection of the right clinical tests can have a significant impact on their survival. However, laboratory findings with current methodologies are often negative, challenging clinicians and laboratorians to continue the search for the responsible pathogen. Novel methodologies are providing increased sensitivity and rapid turnaround time to results but also challenging our interpretation of what is a clinically significant pathogen in cancer patients. This minireview provides an overview of the most common infections in cancer patients and discusses some of the challenges and opportunities for the clinical microbiologist supporting the care of cancer patients.
感染仍然是癌症患者发病和死亡的重要原因。这些患者的鉴别诊断范围通常很广，及时选择正确的临床检查对其生存有重大影响。然而，采用当前方法得到的实验室检查结果往往为阴性，这使得临床医生和检验人员难以找到致病病原体。新方法提高了检测的灵敏度并缩短了出结果的时间，但也让我们对癌症患者中具有临床意义的病原体的解读产生了质疑。本综述概述了癌症患者中最常见的感染，并讨论了临床微生物学家在支持癌症患者护理方面面临的一些挑战和机遇。
