Wan Ahmad Kamil Wan NurHazirah, Zainal Mukarramah, Bandara H M H N, Arzmi Mohd Hafiz
Department of Fundamental Dental and Medical Sciences, Kulliyyah of Dentistry, International Islamic University Malaysia, Kuantan, Pahang, Malaysia.
Cluster of Cancer Research Initiative, Kulliyyah of Dentistry, International Islamic University Malaysia, Kuantan, Pahang, Malaysia.
Malays J Med Sci. 2025 Feb;32(1):6-15. doi: 10.21315/mjms-09-2024-691. Epub 2025 Feb 28.
was listed as a critical fungal priority group pathogen by the World Health Organization (WHO) in 2022. It has become a leading cause of invasive candidiasis in serious nosocomial infections globally. While species, particularly , are linked to cancer development, the role of in carcinogenesis remains unexplored. This scoping review aimed to evaluate the existing evidence on the role of infection in carcinogenesis and its associated risk factors. Following the PRISMA-ScR guidelines, a comprehensive search of three databases was conducted from January 2003 to January 2024 to identify studies addressing the role of infection in cancer development and its associated risk factors. A total of 124 articles were identified, of which six met the inclusion criteria. These studies reported the risk factors associated with infection in cancer patients. The findings showed an increased susceptibility of cancer patients to infections. However, to date, no direct relationship has been reported between infection and cancer development due to the limited accuracy of diagnostic tools. In conclusion, infections increase the susceptibility of cancer patients but are not directly involved in carcinogenesis, indicating the urgency for an accurate diagnostic tool for detection and specialised infection-control measures for cancer patients.
2022年被世界卫生组织(WHO)列为关键真菌重点病原体组。它已成为全球严重医院感染中侵袭性念珠菌病的主要原因。虽然某些菌种,特别是[具体菌种未提及],与癌症发展有关,但[具体菌种未提及]在致癌过程中的作用仍未得到探索。本综述旨在评估关于[具体菌种未提及]感染在致癌过程中的作用及其相关危险因素的现有证据。按照PRISMA-ScR指南,于2003年1月至2024年1月对三个数据库进行了全面检索,以识别探讨[具体菌种未提及]感染在癌症发展中的作用及其相关危险因素的研究。共识别出124篇文章,其中6篇符合纳入标准。这些研究报告了癌症患者中与[具体菌种未提及]感染相关的危险因素。研究结果表明癌症患者对[具体菌种未提及]感染的易感性增加。然而,由于诊断工具的准确性有限,迄今为止尚未报告[具体菌种未提及]感染与癌症发展之间的直接关系。总之,[具体菌种未提及]感染增加了癌症患者的易感性,但并未直接参与致癌过程,这表明迫切需要一种准确的[具体菌种未提及]检测诊断工具以及针对癌症患者的专门感染控制措施。