Morton M R, Parish R C, Spruill W J
College of Pharmacy, University of Georgia, Athens 30602.
Ther Drug Monit. 1989;11(3):347-8. doi: 10.1097/00007691-198905000-00020.
Pentoxifylline, a hemorheologic agent, and its metabolites are structurally similar to theophylline and other xanthines; therefore, they have the potential to interfere with serum assays for theophylline. Any false elevation of theophylline serum concentrations could have a significant impact on drug therapy decisions. Serum was obtained from six elderly subjects who had been taking 400 mg of pentoxifylline three times daily for at least six months. A serum assay using the TDx fluorescence polarization immunoassay failed to detect any measurable amount of theophylline. Normal doses of pentoxifylline and the resulting metabolites do not appear to interfere with the TDx method of serum assay for theophylline.
己酮可可碱是一种血液流变学药物，其代谢产物在结构上与茶碱和其他黄嘌呤类似；因此，它们有可能干扰茶碱的血清检测。茶碱血清浓度的任何假性升高都可能对药物治疗决策产生重大影响。从六名老年受试者中采集血清，这些受试者每天三次服用400毫克己酮可可碱，至少服用了六个月。使用TDx荧光偏振免疫分析法进行的血清检测未能检测到任何可测量的茶碱量。正常剂量的己酮可可碱及其产生的代谢产物似乎不会干扰TDx法对茶碱进行血清检测。
