Davoodi Amirabbas, Boozarjomehry Ramin Bozorgmehry
Chemical and Petroleum Engineering Department, Sharif University of Technology, Azadi Av., Tehran, Iran.
Chemical and Petroleum Engineering Department, Sharif University of Technology, Azadi Av., Tehran, Iran.
Comput Methods Programs Biomed. 2016 Aug;132:1-10. doi: 10.1016/j.cmpb.2016.04.021. Epub 2016 Apr 25.
The human lungs exchange air with the external environment via the conducting airways. The application of an anatomically accurate model of the conducting airways can be helpful for simulating gas exchange and fluid distribution throughout the bronchial tree in the lung.
In the current study, Lindenmayer system (L-system) has been formulated to generate the bronchial tree structure in a human lung. It has been considered that the structure of the bronchial tree is divided into two main segments: 1) The central airways (from the trachea to segmental bronchi) and 2) the dichotomous structure (from segmental bronchi to terminal bronchioles). Two sets of parametric rewriting rules which can be used to develop central and peripheral airways have been proposed; the first set used to develop central airways consists of seven rules, while the second rule set contains four rules.
The proposed model is capable of generating bronchial tree inside the volume of the host lung; and comparison of the resulting model with those reported in the literature shows that the morphometric characteristics of L-system structure are in good agreement with their corresponding experimental data.
The resulting model can be used to obtain a mathematical model required for the study of transport phenomena occurring in the lung during respiration.
人类肺部通过传导气道与外部环境进行气体交换。应用解剖学精确的传导气道模型有助于模拟肺部支气管树中的气体交换和液体分布。
在本研究中，已制定林登迈耶系统（L系统）以生成人类肺部的支气管树结构。已考虑将支气管树结构分为两个主要部分：1）中央气道（从气管到段支气管）和2）二叉分支结构（从段支气管到终末细支气管）。已提出两组可用于构建中央和外周气道的参数重写规则；用于构建中央气道的第一组规则由七条规则组成，而第二组规则包含四条规则。
所提出的模型能够在宿主肺的体积内生成支气管树；将所得模型与文献中报道的模型进行比较表明，L系统结构的形态计量学特征与其相应的实验数据高度吻合。
所得模型可用于获得研究呼吸过程中肺部发生的传输现象所需的数学模型。
