Grimshaw W T, Weatherley A J, Jones R M
Pfizer Central Research, Sandwich, Kent.
Vet Rec. 1989 Apr 29;124(17):453-6. doi: 10.1136/vr.124.17.453.
A novel intraruminal bolus developed for the sustained delivery of the anthelmintic morantel tartrate was evaluated in the seasonal control of parasitic gastroenteritis in first season grazing calves. The morantel sustained release trilaminate is a trilaminate sheet consisting of a central lamina of a morantel tartrate/ethylene vinyl acetate matrix coated on both sides with a thin impermeable layer of ethylene vinyl acetate. A symmetrical pattern of circular perforations punched through the device controls the release of morantel. Administration of the trilaminate to calves significantly reduced their faecal egg output compared with untreated controls and thus reduced pasture larval contamination. Clinical parasitic gastroenteritis was prevented in the treated calves and there were significant reductions in their worm burdens compared with the untreated control calves both during and at the end of the grazing season. The control of parasitic gastroenteritis resulted in a significantly greater (P less than 0.0001) weight gain, of 45 kg, by the treated calves.
一种为持续递送驱虫药酒石酸莫仑太尔而研发的新型瘤胃丸剂，在第一季放牧犊牛的寄生性胃肠炎季节性防控中进行了评估。莫仑太尔缓释三层片是一种三层片材，由酒石酸莫仑太尔/乙烯-醋酸乙烯酯基质的中央层组成，两侧涂有一层薄的乙烯-醋酸乙烯酯不渗透层。贯穿该装置冲压出的圆形穿孔对称图案控制着莫仑太尔的释放。与未处理的对照相比，给犊牛投喂三层片显著降低了它们的粪便虫卵排出量，从而减少了牧场幼虫污染。在治疗的犊牛中预防了临床寄生性胃肠炎，并且在放牧季节期间和结束时，与未处理的对照犊牛相比，它们的蠕虫负担显著降低。寄生性胃肠炎的防控使治疗的犊牛体重显著增加（P小于0.0001），增加了45千克。
