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ts1, a mutant of Moloney murine leukemia virus-TB, causes both immunodeficiency and neurologic disorders in BALB/c mice.

作者信息

Wong P K, Prasad G, Hansen J, Yuen P H

机构信息

University of Texas M.D. Anderson Cancer Center, Department of Carcinogenesis, Smithville 78957.

出版信息

Virology. 1989 Jun;170(2):450-9. doi: 10.1016/0042-6822(89)90436-4.

DOI:10.1016/0042-6822(89)90436-4
PMID:2728346
Abstract

BALB/c mice infected with ts1, a mutant of Moloney murine leukemia virus-TB, develop generalized body wasting, profound neurologic disorders, severe thymic atrophy and lymphopenia due to destruction of T lymphocytes and drastic immunodeficiency. ts1 was found not only able to infect T lymphocytes but also to impair their function. In addition, ts1 also infects and induces syncyntia formation in macrophages. The genetic determinant(s) responsible for ts1's ability to induce immunodeficiency has been localized to the env gene.

摘要

相似文献

1
ts1, a mutant of Moloney murine leukemia virus-TB, causes both immunodeficiency and neurologic disorders in BALB/c mice.
Virology. 1989 Jun;170(2):450-9. doi: 10.1016/0042-6822(89)90436-4.
2
Alteration from T- to B-cell tropism reduces thymic atrophy and cytocidal effects in thymocytes but not neurovirulence induced by ts1, a mutant of Moloney murine leukemia virus TB.
Proc Natl Acad Sci U S A. 1991 Oct 15;88(20):8991-5. doi: 10.1073/pnas.88.20.8991.
3
Murine leukemia virus induced central nervous system diseases.鼠白血病病毒诱发的中枢神经系统疾病。
Leukemia. 1992;6 Suppl 3:161S-165S.
4
High susceptibility of FVB/N mice to the paralytic disease induced by ts1, a mutant of Moloney murine leukemia virus TB.FVB/N小鼠对莫洛尼鼠白血病病毒TB突变体ts1诱导的麻痹性疾病高度易感。
Virology. 1991 Jan;180(1):365-71. doi: 10.1016/0042-6822(91)90041-9.
5
Rudimentary thymus of SCID mouse plays an important role in the development of retrovirus-induced neurologic disorders.重症联合免疫缺陷（SCID）小鼠的原始胸腺在逆转录病毒诱导的神经疾病发展中起重要作用。
Virology. 1993 Jul;195(1):211-8. doi: 10.1006/viro.1993.1362.
6
ts1, a temperature-sensitive mutant of Moloney murine leukemia virus TB, can infect both CD4+ and CD8+ T cells but requires CD4+ T cells in order to cause paralysis and immunodeficiency.ts1是莫洛尼鼠白血病病毒TB的一种温度敏感突变体，它能感染CD4+和CD8+ T细胞，但为了导致麻痹和免疫缺陷，需要CD4+ T细胞。
J Virol. 1992 May;66(5):2639-46. doi: 10.1128/JVI.66.5.2639-2646.1992.
7
The role of the thymus in the pathogenesis of hind-limb paralysis induced by ts1, a mutant of Moloney murine leukemia virus-TB.
Virology. 1989 Apr;169(2):332-40. doi: 10.1016/0042-6822(89)90158-x.
8
Temporal lymphoreticular changes caused by ts1, a paralytogenic mutant of Moloney murine leukemia virus TB.由莫洛尼鼠白血病病毒TB的致麻痹突变体ts1引起的颞部淋巴网状组织变化
Lab Invest. 1992 Apr;66(4):427-36.
9
T, not B, lymphocytes are required for immunodeficiency and paralysis induced by ts1, a mutant of Moloney murine leukemia virus-TB.
Virology. 1991 Aug;183(2):815-20. doi: 10.1016/0042-6822(91)91017-b.
10
Site-directed mutagenesis of the codon for Ile-25 in gPr80env alters the neurovirulence of ts1, a mutant of Moloney murine leukemia virus TB.对gPr80env中异亮氨酸-25密码子进行定点诱变可改变莫洛尼氏鼠白血病病毒TB的突变体ts1的神经毒力。
J Virol. 1990 Nov;64(11):5241-9. doi: 10.1128/JVI.64.11.5241-5249.1990.

引用本文的文献

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Adv Virol. 2011;2011:813651. doi: 10.1155/2011/813651. Epub 2011 Aug 16.
2
Neuroprotective effects of the drug GVT (monosodium luminol) are mediated by the stabilization of Nrf2 in astrocytes.药物 GVT（单钠鲁米诺）的神经保护作用是通过稳定星形胶质细胞中的 Nrf2 来介导的。
Neurochem Int. 2010 May-Jun;56(6-7):780-8. doi: 10.1016/j.neuint.2010.02.017. Epub 2010 Mar 6.
3
Down-regulation of Jab1, HIF-1alpha, and VEGF by Moloney murine leukemia virus-ts1 infection: a possible cause of neurodegeneration.
莫洛尼鼠白血病病毒ts1感染对Jab1、HIF-1α和VEGF的下调作用：神经变性的一个可能原因。
J Neurovirol. 2008 May;14(3):239-51. doi: 10.1080/13550280802093919.
4
Retrovirus-induced oxidative stress with neuroimmunodegeneration is suppressed by antioxidant treatment with a refined monosodium alpha-luminol (Galavit).逆转录病毒诱导的伴有神经免疫退变的氧化应激可通过用精制α-鲁米诺单钠（加拉维特）进行抗氧化治疗得到抑制。
J Virol. 2006 May;80(9):4557-69. doi: 10.1128/JVI.80.9.4557-4569.2006.
5
Astrocytes survive chronic infection and cytopathic effects of the ts1 mutant of the retrovirus Moloney murine leukemia virus by upregulation of antioxidant defenses.星形胶质细胞通过上调抗氧化防御机制，在感染逆转录病毒莫洛尼鼠白血病病毒ts1突变体的慢性感染及细胞病变效应中存活下来。
J Virol. 2006 Apr;80(7):3273-84. doi: 10.1128/JVI.80.7.3273-3284.2006.
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Up-regulation of astrocyte cyclooxygenase-2, CCAAT/enhancer-binding protein-homology protein, glucose-related protein 78, eukaryotic initiation factor 2 alpha, and c-Jun N-terminal kinase by a neurovirulent murine retrovirus.一种神经毒性小鼠逆转录病毒对星形胶质细胞环氧化酶-2、CCAAT/增强子结合蛋白同源蛋白、葡萄糖相关蛋白78、真核起始因子2α和c-Jun氨基末端激酶的上调作用。
J Neurovirol. 2005 Apr;11(2):166-79. doi: 10.1080/13550280590922810.
7
Cardiac disease in transgenic mice expressing human immunodeficiency virus-1 nef in cells of the immune system.在免疫系统细胞中表达人类免疫缺陷病毒1型nef的转基因小鼠的心脏疾病。
Am J Pathol. 2002 Jul;161(1):321-35. doi: 10.1016/S0002-9440(10)64184-3.
8
Enhanced proteolysis of IkappaBalpha and IkappaBbeta proteins in astrocytes by Moloney murine leukemia virus (MoMuLV)-ts1 infection: a potential mechanism of NF-kappaB activation.莫洛尼鼠白血病病毒（MoMuLV）-ts1感染增强星形胶质细胞中IkappaBalpha和IkappaBbeta蛋白的蛋白水解作用：NF-κB激活的潜在机制。
J Neurovirol. 2001 Oct;7(5):466-75. doi: 10.1080/135502801753170327.
9
Studies on the pathology, especially brain lesions, induced by R7, a spontaneous mutant of Moloney murine sarcoma virus 124.对莫洛尼氏鼠肉瘤病毒124的自发突变体R7所诱导的病理学，尤其是脑部病变的研究。
Am J Pathol. 1998 Jun;152(6):1509-20.
10
Correlation of specific virus-astrocyte interactions and cytopathic effects induced by ts1, a neurovirulent mutant of Moloney murine leukemia virus.莫洛尼鼠白血病病毒神经毒力突变体ts1诱导的特定病毒-星形胶质细胞相互作用与细胞病变效应的相关性
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