Gorozhanskaia E G, Gromova E G, Sviridova S P
Vopr Onkol. 1989;35(4):436-41.
Urine and blood levels of ascorbic acid (AA) were measured in healthy subjects (40), cases of cancer of the lung (74), stomach (32) and esophagus (12). AA levels were decreased in cancer patients, particularly, in those with gastric and esophageal tumors. A correlation between the decrease of AA level and the increase in blood concentrations of malonic and pyruvic acids was established. Administration of 1.5 g AA for 7 days was followed by blood-AA level returning practically to normal matched by decrease in lactate and pyruvate concentrations. Also, a correlation between postoperative complication frequency and AA deficit was shown. Correction of AA level was found to be an effective means of postoperative complication prevention.
在健康受试者（40例）、肺癌患者（74例）、胃癌患者（32例）和食管癌患者（12例）中测量了尿液和血液中的抗坏血酸（AA）水平。癌症患者的AA水平降低，尤其是患有胃和食管肿瘤的患者。建立了AA水平降低与丙二酸和丙酮酸血液浓度升高之间的相关性。连续7天给予1.5g AA后，血液AA水平几乎恢复正常，同时乳酸和丙酮酸浓度降低。此外，还显示了术后并发症发生率与AA缺乏之间的相关性。发现纠正AA水平是预防术后并发症的有效手段。
