Yan Hua, Luo Kai, Liu Baolong, Kang Jianmin
Department of Neurosurgery, Tianjin Huanhu Hospital, Tianjin 300060, P.R. China.
Department of Ultrasonography, Tianjin Huanhu Hospital, Tianjin 300060, P.R. China.
Oncol Lett. 2016 Jun;11(6):3655-3659. doi: 10.3892/ol.2016.4486. Epub 2016 Apr 20.
The present study describes a case of a solitary fibrous tumor (SFT) concurrent with meningioma in the same anatomical region. The patient was admitted to Tianjin Huanhu Hospital (Tianjin, China) presenting with progressive eyesight impairment, dizziness and right hemiparesis. Cranial magnetic resonance imaging revealed two primary tumors co-occurring at the same site. One lesion was a solid lesion located in the left frontal convex with homogeneous enhancement, and was closely associated with the dura mater; thus, it was suspected that the lesion was a meningioma. The second lesion was cystic and solid with an irregular shape, and was located next to the first tumor; this lesion was believed to be a hemangiopericytoma or astrocytoma. The patient underwent a left temporoparietal craniectomy and a complete excision of the two tumors was achieved. Subsequent pathological examination of the resected tissues confirmed that the two tumors were a secretory meningioma and a SFT, respectively. Immunohistochemistry is important in differentiating SFTs from other tumors. Currently, a total tumor resection is the optimal treatment strategy when managing these rare lesions, often with no requirement for adjuvant post-operative therapy; however, long-term follow-up is essential to detect any signs of recurrence. The possibility of multiple tumors should be taken into consideration when performing clinical examination. To further understand the mechanisms underlying the occurrence of multiple intracranial tumors, further research is required, alongside an increased number of case reports.
本研究描述了一例在同一解剖区域同时存在孤立性纤维瘤(SFT)和脑膜瘤的病例。患者入住天津环湖医院(中国天津),表现为进行性视力损害、头晕和右侧偏瘫。头颅磁共振成像显示在同一部位同时存在两个原发性肿瘤。一个病灶是位于左额凸面的实性病灶,强化均匀,与硬脑膜关系密切,因此怀疑该病灶为脑膜瘤。第二个病灶为囊实性,形状不规则,位于第一个肿瘤旁边;该病灶被认为是血管外皮细胞瘤或星形细胞瘤。患者接受了左颞顶开颅手术,成功完整切除了这两个肿瘤。随后对切除组织进行的病理检查证实,这两个肿瘤分别为分泌型脑膜瘤和SFT。免疫组织化学对于鉴别SFT与其他肿瘤很重要。目前,对于这些罕见病变,完整切除肿瘤是最佳治疗策略,通常无需术后辅助治疗;然而,长期随访对于发现任何复发迹象至关重要。进行临床检查时应考虑到多发肿瘤的可能性。为了进一步了解颅内多发肿瘤发生的机制,需要开展更多的研究以及增加病例报告数量。