Ackerman B H, Olsen K M, Kennedy E E, Taylor E H, Chen B H, Jordan D, Ackerman D J
Department of Pharmacy Practice, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock 72205.
DICP. 1989 May;23(5):375-8. doi: 10.1177/106002808902300504.
The formation rate constant and elimination rate constant for 3-hydroxyquinidine were determined in eight patients with ventricular tachycardia. These two parameters (mean +/- SD) were found to be 0.784 +/- 0.202 and 0.042 +/- 0.058 h-1, respectively. Coefficients of determination for the computer-generated line of best fit for serum concentration-time data were 0.986 +/- 0.008. Patients received two infusions of quinidine gluconate 5 mg/kg over 30 minutes separated by a 20-30 minute electrophysiologic testing period. Unbound and total 3-hydroxyquinidine concentrations were also determined. Among the eight patients, 3-hydroxyquinidine was 61.9 percent bound. Studies in healthy volunteers had shown 50 percent binding. Linear regression of unbound and total 3-hydroxyquinidine was described by the equation Y = 0.3814X-1.448, r = 0.813. Although half-lives of 3.5-12.4 hours had been reported in healthy volunteers, prolonged half-lives were observed in all but two of our arrhythmia patients.
在8例室性心动过速患者中测定了3-羟基奎尼丁的生成速率常数和消除速率常数。发现这两个参数（平均值±标准差）分别为0.784±0.202和0.042±0.058 h⁻¹。血清浓度-时间数据的计算机生成最佳拟合线的决定系数为0.986±0.008。患者接受两次30分钟内静脉输注5mg/kg葡萄糖酸奎尼丁，中间间隔20 - 30分钟的电生理测试期。还测定了游离和总3-羟基奎尼丁浓度。在这8例患者中，3-羟基奎尼丁的蛋白结合率为61.9%。健康志愿者的研究显示结合率为50%。游离和总3-羟基奎尼丁的线性回归方程为Y = 0.3814X - 1.448，r = 0.813。虽然健康志愿者中报道的半衰期为3.5 - 12.4小时，但在我们的心律失常患者中，除2例患者外，其余患者均观察到半衰期延长。
