Chen Q, Yin Y X, Wei J, Tong M, Shen F, Zhao M, Chamley L
The Hospital of Obstetrics & Gynaecology, Fudan University, China; Department of Obstetrics & Gynaecology, The University of Auckland, New Zealand.
Wuxi maternity and Children Hospital, Nanjing Medical University, China.
Cytokine. 2016 Sep;85:30-6. doi: 10.1016/j.cyto.2016.06.001. Epub 2016 Jun 7.
Preeclampsia is a pregnancy-specific disorder characterised by an inappropriate maternal inflammatory response during pregnancy. High mobility group box 1 (HMGB1) was originally characterised as a nuclear protein but when released into the extracellular environment following necrotic cell death, it is proinflammatory. HMGB1 is expressed in the syncytiotrophoblast of human placenta. Higher levels of uric acid are reported in preeclampsia. The aim of this study was to investigate whether the expression of HMGB1differed between early onset and late onset preeclampsia or severe and mild preeclampsia and whether its expression correlated with the levels of uric acid.
74 preeclamptic placentae and 110 normotensive placentae were included in this study. The levels of uric acid in women with preeclampsia were measured. The expression of HMGB1 in preeclamptic placentae or in first trimester and term placentae that had been treated with uric acid was measured.
HMGB1 was expressed predominantly in the syncytiotrophoblast of the placenta and the expression of HMGB1 in the cytoplasm of the syncytiotrophoblast was significantly increased in both severe preeclampsia and early onset preeclampsia compared to normotensive pregnancies. The circulating levels of uric acid were significantly increased in preeclampsia and correlated with the expression of HMGB1. Increased levels of HMGB1 were significantly correlated with the severity and the time of onset of preeclampsia, but pathologic levels of uric acid did not increase the expression of HMGB1.
Our data provides a better understanding of the function of HMGB1, a danger molecule in the pathogenesis of preeclampsia.
子痫前期是一种妊娠特有的疾病，其特征是孕期母体出现不适当的炎症反应。高迁移率族蛋白B1（HMGB1）最初被鉴定为一种核蛋白，但在坏死性细胞死亡后释放到细胞外环境中时，它具有促炎作用。HMGB1在人胎盘的合体滋养层中表达。据报道，子痫前期患者的尿酸水平较高。本研究的目的是调查早发型和晚发型子痫前期或重度和轻度子痫前期中HMGB1的表达是否存在差异，以及其表达是否与尿酸水平相关。
本研究纳入了74例子痫前期胎盘和110例血压正常的胎盘。测量子痫前期患者的尿酸水平。检测子痫前期胎盘或经尿酸处理的孕早期和足月胎盘组织中HMGB1的表达。
HMGB1主要在胎盘的合体滋养层中表达，与血压正常的妊娠相比，重度子痫前期和早发型子痫前期患者合体滋养层细胞质中HMGB1的表达均显著增加。子痫前期患者的循环尿酸水平显著升高，且与HMGB1的表达相关。HMGB1水平的升高与子痫前期的严重程度和发病时间显著相关，但病理性尿酸水平并未增加HMGB1的表达。
我们的数据有助于更好地理解HMGB1在子痫前期发病机制中的危险分子功能。
